Body mass index associated with childhood and adolescent high-risk B-cell acute lymphoblastic leukemia risk: A Children's Oncology Group report.
Body mass index associated with childhood and adolescent high-risk B-cell acute lymphoblastic leukemia risk: A Children's Oncology Group report.
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DOI：
10.1002/cam4.3334
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发表时间：
2020-09
期刊：
影响因子：
4
通讯作者：
Turcotte LM
中科院分区：
文献类型：
--
作者：
Ghosh T;Richardson M;Gordon PM;Ryder JR;Spector LG;Turcotte LM
肥胖是许多成年期癌症的危险因素，但其在儿童、青少年和青年（AYA）癌症中的作用尚不清楚。儿童和AYA急性淋巴细胞白血病（ALL）发病率和肥胖患病率同时增加。我们试图确定肥胖是否可能是儿童和AYA ALL的危险因素。将2004 - 2017年诊断并根据儿童肿瘤组（COG）方案治疗的2 - 30岁ALL患者（N = 4726）的特征与国家健康和营养检查调查对照（COG AALL 17 D2）进行比较。使用标准CDC定义定义体重指数（BMI）。多变量条件logistic回归评估BMI与ALL之间的相关性，并按性别和种族/民族进行额外分析。在病例（72%高危（HR）B-ALL，28% T-ALL）中，5%体重不足，58%体重正常，17%超重，20%肥胖。体重不足（OR 2.11，95% CI 1.56 - 2.85）和肥胖（OR 1.32，95% CI 1.15 - 1.53）与B-ALL诊断相关。具体而言，肥胖与男性（OR 1.57，95% CI 1.30 - 1.91）和西班牙裔儿童（OR 1.78，95% CI 1.39 - 2.29）中的B-ALL相关。肥胖也与中枢神经系统（CNS）受累有关。治疗前肥胖与男性和西班牙裔中的HR B-ALL相关，以及与CNS受累相关，表明肥胖和白血病发生之间存在共同的生理学。体重过轻与ALL之间的相关性得到证实，可能是由于癌症相关的消瘦。这些结果对预防和治疗儿童和青少年肥胖以降低癌症风险具有重要的公共卫生意义。与正常体重相比，诊断时的体重指数偏差（体重不足和肥胖）与儿科高危（HR）B细胞急性淋巴细胞白血病（B-ALL）的诊断显著相关。具体而言，肥胖与男性和西班牙裔的HR B-ALL相关。肥胖也与ALL中枢神经系统（CNS）受累显著相关。
Obesity is a risk factor for many adulthood cancers, but its role in childhood, adolescent, and young adult (AYA) cancer is unknown. Childhood and AYA acute lymphoblastic leukemia (ALL) incidence and obesity prevalence have shown concurrent increases. We sought to identify whether obesity may be a risk factor for childhood and AYA ALL. Characteristics from individuals with ALL, aged 2‐30 years, diagnosed 2004‐2017 and treated on Children's Oncology Group (COG) protocols with available pre‐treatment anthropometric data (N = 4726) were compared to National Health and Nutrition Examination Survey controls (COG AALL17D2). Body mass index (BMI) was defined using standard CDC definitions. Multivariate conditional logistic regression assessed associations between BMI and ALL with additional analyses stratified by sex and race/ethnicity. Among cases (72% high‐risk (HR) B‐ALL, 28% T‐ALL), 5% had underweight, 58% normal weight, 17% overweight, and 20% obesity. Underweight (OR 2.11, 95% CI 1.56‐2.85) and obesity (OR 1.32, 95% CI 1.15‐1.53) were associated with B‐ALL diagnosis. Specifically, obesity was associated with B‐ALL among males (OR 1.57, 95% CI 1.30‐1.91) and Hispanic children (OR 1.78, 95% CI 1.39‐2.29). Obesity was also associated with central nervous system (CNS) involvement. Pre‐treatment obesity is associated with HR B‐ALL among males and Hispanics, as well as with CNS involvement, suggesting common physiology between obesity and leukemogenesis. An association between underweight and ALL was confirmed, likely due to cancer‐associated wasting. These results have important public health implications for obesity prevention and treatment in children and adolescents to reduce cancer risk. Deviations in body mass index (underweight and obesity) at the time of diagnosis were significantly associated with a diagnosis of pediatric high‐risk (HR) B‐cell acute lymphoblastic leukemia (B‐ALL) compared to normal weight. Specifically, obesity was associated with HR B‐ALL in males and Hispanics. Obesity was also significantly associated with ALL central nervous system (CNS) involvement.
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DOI：
10.1111/obr.12358
发表时间：
2016-03
期刊：
Obesity reviews : an official journal of the International Association for the Study of Obesity
影响因子：
--
作者：
Heymsfield SB;Peterson CM;Thomas DM;Heo M;Schuna JM Jr
通讯作者：
Schuna JM Jr
影响因子：
11.1
作者：
Gustafson, D. R.;Karlsson, C.;Blennow, K.
通讯作者：
Blennow, K.
影响因子：
8.2
作者：
Ohkuma T;Peters SAE;Woodward M
通讯作者：
Woodward M
DOI：
10.1037/lat0000054
发表时间：
2016-05-01
期刊：
JOURNAL OF LATINA-O PSYCHOLOGY
影响因子：
--
作者：
Isasi, Carmen R.;Rastogi, Deepa;Molina, Kristine
通讯作者：
Molina, Kristine
影响因子：
3.8
作者：
Mouzaki, Athanasia;Panagoulias, Ioannis;Georgakopoulos, Tassos
通讯作者：
Georgakopoulos, Tassos