Sex differences in the association between diabetes and cancer: a systematic review and meta-analysis of 121 cohorts including 20 million individuals and one million events.
Sex differences in the association between diabetes and cancer: a systematic review and meta-analysis of 121 cohorts including 20 million individuals and one million events.
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DOI：
10.1007/s00125-018-4664-5
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发表时间：
2018-10
期刊：
影响因子：
8.2
通讯作者：
Woodward M
中科院分区：
文献类型：
--
作者：
Ohkuma T;Peters SAE;Woodward M
糖尿病已被证明是某些癌症的危险因素。糖尿病是否在女性和男性中赋予相同的癌症额外风险，总体和部位尚不清楚。在PubMed中对截至2016年12月发表的队列研究进行了系统检索。选定的研究报告了性别特异性相对风险（RR）估计糖尿病和癌症之间的关联调整，至少在男性和女性的年龄。使用具有逆方差加权的随机效应荟萃分析来获得所有部位和部位特异性癌症的汇总性别特异性RR和女性与男性的RR比（RRRs）。121个队列（19，239，302例个体; 1，082，592起事件）的所有部位癌症事件（仅事件或致死性）数据可用。女性和男性中与糖尿病相关的所有部位癌症的合并校正RR分别为1.27（95% CI 1.21，1.32）和1.19（1.13，1.25）。与男性糖尿病患者相比，女性糖尿病患者的风险高约6%（合并的RRR为1.06，95% CI 1.03，1.09）。所有部位癌症发病率的相应汇总RR为1.10（1.07，1.13），所有部位癌症死亡率的相应汇总RR为1.03（0.99，1.06）。糖尿病也使女性口腔癌、胃癌和肾癌以及白血病的RR显著高于男性，但肝癌的RR较低。糖尿病是女性和男性所有部位癌症的风险因素，但女性患糖尿病相关癌症的过度风险略高于男性。性别差异的方向和程度因癌症部位而异。本文的在线版本（10.1007/s 00125 -018-4664-5）包含同行评审但未经编辑的补充材料，可供授权用户使用。
Diabetes has been shown to be a risk factor for some cancers. Whether diabetes confers the same excess risk of cancer, overall and by site, in women and men is unknown. A systematic search was performed in PubMed for cohort studies published up to December 2016. Selected studies reported sex-specific relative risk (RR) estimates for the association between diabetes and cancer adjusted at least for age in both sexes. Random-effects meta-analyses with inverse-variance weighting were used to obtain pooled sex-specific RRs and women-to-men ratios of RRs (RRRs) for all-site and site-specific cancers. Data on all-site cancer events (incident or fatal only) were available from 121 cohorts (19,239,302 individuals; 1,082,592 events). The pooled adjusted RR for all-site cancer associated with diabetes was 1.27 (95% CI 1.21, 1.32) in women and 1.19 (1.13, 1.25) in men. Women with diabetes had ~6% greater risk compared with men with diabetes (the pooled RRR was 1.06, 95% CI 1.03, 1.09). Corresponding pooled RRRs were 1.10 (1.07, 1.13) for all-site cancer incidence and 1.03 (0.99, 1.06) for all-site cancer mortality. Diabetes also conferred a significantly greater RR in women than men for oral, stomach and kidney cancer, and for leukaemia, but a lower RR for liver cancer. Diabetes is a risk factor for all-site cancer for both women and men, but the excess risk of cancer associated with diabetes is slightly greater for women than men. The direction and magnitude of sex differences varies by location of the cancer. The online version of this article (10.1007/s00125-018-4664-5) contains peer-reviewed but unedited supplementary material, which is available to authorised users.
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影响因子：
3.8
作者：
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通讯作者：
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影响因子：
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影响因子：
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影响因子：
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DOI：
10.1111/j.1753-6405.2010.00532.x
发表时间：
2010-06-01
影响因子：
3.5
作者：
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通讯作者：
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