Drug release kinetics from monolayer films of glucose-sensitive microgel
Drug release kinetics from monolayer films of glucose-sensitive microgel
复制标题
葡萄糖敏感微凝胶单层膜的药物释放动力学
DOI：
10.1016/j.polymer.2010.04.011
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发表时间：
2010-05
期刊：
影响因子：
4.6
通讯作者：
Luo, Qiaofang
中科院分区：
文献类型：
--
作者：
Zhang, Yongjun;Guan, Ying;Liu, Pengxiao;Luo, Qiaofang
为了研究葡萄糖敏感的聚(N-异丙基丙烯酰胺-共-3-丙烯酰胺苯硼酸)(P(NIPAM-PBA))微凝胶的药物释放行为，在EDC催化下，通过3-氨基苯硼酸对聚(N-异丙基丙烯酰胺-共-丙烯酸)微凝胶单层进行改性，制备了P(NIPAM-PBA)微凝胶单层。将茜素红 S (ARS) 和 FITC 标记的胰岛素 (FITC-insulin) 分别加载到单层细胞中。测量了它们在不同条件下的释放动力学。对于这两种药物，在低温下，药物释放可以描述为药物的被动扩散。然而，在高于相变温度的温度下，药物通过“挤出”机制释放。观察到两种药物的葡萄糖调节释放。在所有温度下，葡萄糖都会增强 ARS 的释放，因为它与 ARS 竞争与 PBA 基团的结合。对于 FITC-胰岛素，葡萄糖在 4 °C 时会增强其释放，但在 37 °C 时会延迟释放。这些结果将指导基于 P(NIPAM-PBA) 微凝胶的自我调节胰岛素释放系统的设计。
To study the drug release behaviors of glucose-sensitive poly(N-isopropylacrylamide-co-3-acrylamidophenylboronic acid) (P(NIPAM-PBA)) microgels, P(NIPAM-PBA) microgel monolayers were prepared by the modification of poly(N-isopropylacrylamide-co-acrylic acid) microgel monolayers with 3-aminophenylboronic acid under EDC catalysis. Alizarin Red S (ARS) and FITC-labeled insulin (FITC-insulin) were loaded in the monolayers respectively. Their release kinetics under various conditions were measured. For both drugs, at low temperature, the drug release can be described as passive diffusion of the drugs. At temperature higher than the phase transition temperature, however, the drugs are released via a “squeeze-out” mechanism. Glucose-regulated release for both drugs was observed. At all temperatures glucose enhances the release of ARS because it competes with ARS for binding with PBA groups. For FITC-insulin, glucose enhances its release at 4 °C, but retards at 37 °C. These results will guide the design of self-regulated insulin release systems based on P(NIPAM-PBA) microgels.
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影响因子：
6.2
作者：
Matsumoto, A;Yoshida, R;Kataoka, K
通讯作者：
Kataoka, K
影响因子：
7.4
作者：
Alexeev, VL;Sharma, AC;Asher, SA
通讯作者：
Asher, SA
DOI：
10.1016/0166-6622(86)80274-8
发表时间：
1986-10-01
期刊：
COLLOIDS AND SURFACES
影响因子：
--
作者：
PELTON, RH;CHIBANTE, P
通讯作者：
CHIBANTE, P
影响因子：
3.3
作者：
Varga, I;Gilányi, T;Zrínyi, M
通讯作者：
Zrínyi, M
影响因子：
6.2
作者：
Matsumoto, A;Ikeda, S;Kataoka, K
通讯作者：
Kataoka, K