Scaling and coordination deficits during dynamic object manipulation in Parkinson's disease.
Scaling and coordination deficits during dynamic object manipulation in Parkinson's disease.
复制标题
帕金森病动态物体操纵过程中的尺度和协调缺陷。
DOI：
10.1152/jn.00041.2014
复制
发表时间：
2014
影响因子：
2.5
通讯作者：
Poizner,Howard
中科院分区：
文献类型：
--
作者：
Snider,Joseph;Lee,Dongpyo;Harrington,DeborahL;Poizner,Howard
以灵巧的方式达到和动态操纵物体的能力需要手臂、手和指尖力量在达到和抓住这种行为的组成部分时的缩放和协调。动态对象操作背后的神经基质尚未被很好地理解。基底神经节-丘脑皮质回路在物体操纵中的作用可以从帕金森病（PD）患者的研究中获得。我们假设运动控制的尺度和协调方面受到这种疾病的不同影响。我们要求20名PD患者和23名年龄匹配的对照受试者沿着规定的路径伸手、抓握和举起虚拟物体。通过检测其潜在的自相似性，将运动细分为两种类型，密集（缩放）和协调。与对照组相比，停药的PD患者在运动的两个方面都明显受损。在到达期间，可以看到密集的缺陷，峰值速度和孔径降低。在到达期间，即沿轨迹的相对位置，即达到峰值速度和孔径时，以及在上升期间，当物体相对于引力轴倾斜时，观察到协调缺陷。这些结果表明，基底神经节-丘脑皮层回路可能在精细运动协调中起重要作用。多巴胺能疗法显著改善密集但不协调方面的运动。这些发现与一个框架是一致的，在这个框架中，背纹状体中的多巴胺的张力水平编码运动的能量消耗，从而改善运动的密集或扩展方面。然而，大脑多巴胺水平的补充并不能恢复精细协调的运动。
The ability to reach for and dynamically manipulate objects in a dexterous fashion requires scaling and coordination of arm, hand, and fingertip forces during reach and grasp components of this behavior. The neural substrates underlying dynamic object manipulation are not well understood. Insight into the role of basal ganglia-thalamocortical circuits in object manipulation can come from the study of patients with Parkinson's disease (PD). We hypothesized that scaling and coordination aspects of motor control are differentially affected by this disorder. We asked 20 PD patients and 23 age-matched control subjects to reach for, grasp, and lift virtual objects along prescribed paths. The movements were subdivided into two types, intensive (scaling) and coordinative, by detecting their underlying self-similarity. PD patients off medication were significantly impaired relative to control subjects for both aspects of movement. Intensive deficits, reduced peak speed and aperture, were seen during the reach. Coordinative deficits were observed during the reach, namely, the relative position along the trajectory at which peak speed and aperture were achieved, and during the lift, when objects tilted with respect to the gravitational axis. These results suggest that basal ganglia-thalamocortical circuits may play an important role in fine motor coordination. Dopaminergic therapy significantly improved intensive but not coordinative aspects of movements. These findings are consistent with a framework in which tonic levels of dopamine in the dorsal striatum encode the energetic cost of a movement, thereby improving intensive or scaling aspects of movement. However, repletion of brain dopamine levels does not restore finely coordinated movement.
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DOI：
--
发表时间：
1981
期刊：
Attention and Performance
影响因子：
--
作者：
M. Jeannerod
通讯作者：
M. Jeannerod
影响因子：
16.2
作者：
Snider, Joseph;Pillai, Andrea;Stevens, Charles F.
通讯作者：
Stevens, Charles F.
影响因子：
2.5
作者：
R. Turner;M. Desmurget;J. Grethe;M. D. Crutcher;Scott T. Grafton
通讯作者：
R. Turner;M. Desmurget;J. Grethe;M. D. Crutcher;Scott T. Grafton
影响因子：
2.5
作者：
Boraud, T;Bezard, E;Gross, CE
通讯作者：
Gross, CE
影响因子：
14.5
作者：
Maschke, M;Gomez, CM;Konczak, J
通讯作者：
Konczak, J