Mechanisms for the metabolic success of bariatric surgery.

Mechanisms for the metabolic success of bariatric surgery.
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DOI:
10.1111/jne.12708
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发表时间:
2019-05
影响因子:
3.2
通讯作者:
--
中科院分区:
医学3区
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--
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迄今为止,减肥手术仍然是治疗肥胖及其合并症的最有效策略。然而,考虑到肥胖流行病的严重性,以及有时可变的结果,它不是治疗所有肥胖患者的可行策略。一个简单的PubMed搜索“减肥手术”显示,自20世纪40年代第一次减肥手术以来,已经发表了超过28000篇论文。然而,对于手术减肥和代谢成功的机制仍然没有完全了解。了解的机制是很重要的,因为它可能会导致更好地了解肥胖的病理生理学,从而手术治疗所有肥胖患者的替代策略。在这篇综述中,讨论了手术成功的潜在机制,重点是潜在的内分泌,神经和其他循环因素(如胆汁酸),已提出发挥作用。
To date, bariatric surgery remains the most effective strategy for the treatment of obesity and its comorbidities. However, given the enormity of the obesity epidemic, and sometimes variable results, it is not a feasible strategy for the treatment of all obese patients. A simple PubMed search for ‘bariatric surgery’ reveals over 28 000 papers that have been published since the 1940s when the first bariatric surgeries were performed. However, there is still an incomplete understanding of the mechanisms for the weight loss and metabolic success of surgery. An understanding of the mechanisms is important because it may lead to greater understanding of the pathophysiology of obesity and thus surgery-alternative strategies for the treatment of all obese patients. In this review, the potential mechanisms that underlie the success of surgery are discussed, with a focus on the potential endocrine, neural and other circulatory factors (eg, bile acids) that have been proposed to play a role.
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