Adiposity and NMR-measured lipid and metabolic biomarkers among 30,000 Mexican adults.
Adiposity and NMR-measured lipid and metabolic biomarkers among 30,000 Mexican adults.
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DOI：
10.1038/s43856-022-00208-2
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发表时间：
2022-11-14
期刊：
影响因子：
--
通讯作者：
Tapia-Conyer, Roberto
中科院分区：
文献类型：
--
作者：
Aguilar-Ramirez, Diego;Herrington, William G.;Alegre-Diaz, Jesus;Staplin, Natalie;Ramirez-Reyes, Raul;Gnatiuc, Louisa Friedrichs;Hill, Michael;Romer, Frederik;Trichia, Eirini;Bragg, Fiona;Wade, Rachel;Lewington, Sarah;Collins, Rory;Emberson, Jonathan R.;Kuri-Morales, Pablo;Tapia-Conyer, Roberto
肥胖是发病和死亡的主要原因，部分原因是对血脂的影响。核磁共振（NMR）光谱提供了关于>130种主要与血脂颗粒相关的生物标志物的直接信息。在28，934名没有慢性疾病且未接受降脂治疗的墨西哥成年人中，我们检查了体重指数（BMI），腰围（WC），腰臀比（WHR）和臀围（HC）与NMR测量的代谢生物标志物的横截面相关性。在相互调整其他肥胖测量之前和之后，估计每个肥胖测量和NMR生物标志物之间的混淆调整关联。全身（即BMI）、腹部（即WC和WHR）和臀股（即HC）肥胖的标志物在NMR平台的生物标志物中均显示出相似且强烈的相关性，特别是增加心脏代谢风险的生物标志物。肥胖与载脂蛋白B水平升高有关（BMI、WHR、WC和HC每增加2个SD，载脂蛋白-B分别增加约0.35、0.30、0.35和0.25 SD），极低密度脂蛋白颗粒水平升高（以及这些脂蛋白中的胆固醇、甘油三酯和磷脂），所有脂肪酸（特别是单不饱和脂肪酸）的水平更高，以及其他代谢生物标志物的多种变化，包括支链氨基酸和炎症生物标志物糖蛋白乙酰基的水平更高。全身肥胖和腹部肥胖的相关性是相当独立的，但是，考虑到全身肥胖和腹部肥胖，较高的臀股脂肪与强烈有利的心脏代谢脂质谱相关。我们的研究结果提供了洞察不同的肥胖标志物在以前研究不足的人群中，肥胖是常见的，但降脂治疗是不。肥胖增加了多种疾病的风险，部分原因是身体分解碳水化合物和脂肪的方式发生了变化，这反映在血液循环的分子中。在肥胖症中，疾病风险可能会有所不同，这取决于脂肪是否在身体整体（即总肥胖症），身体中部（即腹部肥胖症）或臀部周围（即臀股肥胖症）积聚。在这里，我们表明，在墨西哥成年人中，较高的总脂肪和腹部脂肪与血液中与2型糖尿病和心脏病有关的许多分子有着不利的关系，而较高的臀股脂肪与血液中与2型糖尿病和心脏病有关的许多分子有着有利的关系。这些发现提供了关于在肥胖率高的人群中将全身脂肪积累与疾病风险联系起来的过程的见解。Aguilar-Ramirez等人研究了墨西哥成年人肥胖和代谢特征之间的横断面关联。他们的研究结果表明，较高的总脂肪和中心性脂肪与许多与疾病风险相关的代谢因素存在不利关系，而较高的臀股脂肪与许多与疾病风险相关的代谢因素存在有利关系。
Adiposity is a major cause of morbidity and mortality in part due to effects on blood lipids. Nuclear magnetic resonance (NMR) spectroscopy provides direct information on >130 biomarkers mostly related to blood lipid particles. Among 28,934 Mexican adults without chronic disease and not taking lipid-lowering therapy, we examine the cross-sectional relevance of body-mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), and hip circumference (HC) to NMR-measured metabolic biomarkers. Confounder-adjusted associations between each adiposity measure and NMR biomarkers are estimated before and after mutual adjustment for other adiposity measures. Markers of general (ie, BMI), abdominal (ie, WC and WHR) and gluteo-femoral (ie, HC) adiposity all display similar and strong associations across the NMR-platform of biomarkers, particularly for biomarkers that increase cardiometabolic risk. Higher adiposity associates with higher levels of Apolipoprotein-B (about 0.35, 0.30, 0.35, and 0.25 SD higher Apolipoprotein-B per 2-SD higher BMI, WHR, WC, and HC, respectively), higher levels of very low-density lipoprotein particles (and the cholesterol, triglycerides, and phospholipids within these lipoproteins), higher levels of all fatty acids (particularly mono-unsaturated fatty acids) and multiple changes in other metabolic biomarkers including higher levels of branched-chain amino acids and the inflammation biomarker glycoprotein acetyls. Associations for general and abdominal adiposity are fairly independent of each other but, given general and abdominal adiposity, higher gluteo-femoral adiposity is associated with a strongly favourable cardiometabolic lipid profile. Our results provide insight to the lipidic and metabolomic signatures of different adiposity markers in a previously understudied population where adiposity is common but lipid-lowering therapy is not. Obesity increases the risk of multiple diseases, in part due to alterations in how the body breaks down carbohydrates and fats, which is reflected in molecules that circulate in blood. In obesity, disease risk may vary depending on whether fat accumulates in the body overall (i.e. total adiposity), in the middle of the body (i.e. abdominal adiposity) or around the hips (i.e. gluteo-femoral adiposity). Here, we show that in a population of Mexican adults higher total and abdominal adiposity relate adversely, while higher gluteo-femoral adiposity relates favourably, to numerous molecules in blood that are linked to type 2 diabetes and heart disease. These findings provide insight on the processes that link the accumulation of fat across the body with disease risk in a population where obesity rates are high. Aguilar-Ramirez et al. examine cross-sectional associations between adiposity and metabolic traits among Mexican adults. Their findings suggest that higher total and central adiposity relate adversely, whilst higher gluteo-femoral adiposity relates favourably, to numerous metabolic factors relevant to disease risk.
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