Associations among Cognitive Functions, Plasma DNA, and Diffusion Tensor Image along the Perivascular Space (DTI-ALPS) in Patients with Parkinson's Disease.
Associations among Cognitive Functions, Plasma DNA, and Diffusion Tensor Image along the Perivascular Space (DTI-ALPS) in Patients with Parkinson's Disease.
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DOI：
10.1155/2021/4034509
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发表时间：
2021
影响因子：
--
通讯作者：
Lin WC
中科院分区：
文献类型：
--
作者：
Chen HL;Chen PC;Lu CH;Tsai NW;Yu CC;Chou KH;Lai YR;Taoka T;Lin WC
帕金森病（PD）是一种常见的神经退行性疾病，与错误折叠蛋白的积累和神经炎症的增加有关，这可能进一步损害淋巴系统。本研究的目的是利用沿血管周围间隙扩散张量图像分析（DTI-ALPS）来评估PD患者淋巴系统活性及其与全身氧化应激状态的关系。对25例认知正常（PDN） PD患者、25例轻度认知障碍（PD- mci） PD患者、38例痴呆（PDD） PD患者和47例正常对照（NC） PD患者进行磁共振成像和神经心理测试。血浆DNA水平评价氧化应激状态。评估各组间alps指数的差异，并进一步与认知功能和血浆DNA水平相关。PD-MCI组和PDD组alps指数明显低于正常对照组。alps指数与血浆核DNA、线粒体DNA水平和认知评分呈负相关。以较低的alps指数为代表的沿血管周围间隙较低的弥漫性表明PD患者的淋巴系统受损。血浆核DNA水平升高与alps指数降低之间的相关性支持了PD患者可能表现出与淋巴系统微结构改变相关的氧化应激增加的观点。
Parkinson's disease (PD) is a common neurodegenerative disease associated with accumulation of misfolding proteins and increased neuroinflammation, which may further impair the glymphatic system. The purpose of this study was to utilize diffusion tensor image analysis along the perivascular space (DTI-ALPS) to evaluate glymphatic system activity and its relationship with systemic oxidative stress status in PD patients. Magnetic resonance imaging and neuropsychological tests were conducted on 25 PD patients with normal cognition (PDN), 25 PD patients with mild cognitive impairment (PD-MCI), 38 PD patients with dementia (PDD), and 47 normal controls (NC). Oxidative stress status was assessed by plasma DNA level. Differences in ALPS-index among the subgroups were assessed and further correlated with cognitive functions and plasma DNA levels. The PD-MCI and PDD groups showed significantly lower ALPS-index compared to normal controls. The ALPS-index was inversely correlated with plasma nuclear DNA, mitochondrial DNA levels, and cognitive scores. Lower diffusivity along the perivascular space, represented by lower ALPS-index, indicates impairment of the glymphatic system in PD patients. The correlation between elevated plasma nuclear DNA levels and lower ALPS-index supports the notion that PD patients may exhibit increased oxidative stress associated with glymphatic system microstructural alterations.
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DOI：
10.1126/science.1241224
发表时间：
2013-10-18
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Xie L;Kang H;Xu Q;Chen MJ;Liao Y;Thiyagarajan M;O'Donnell J;Christensen DJ;Nicholson C;Iliff JJ;Takano T;Deane R;Nedergaard M
通讯作者：
Nedergaard M
影响因子：
5.3
作者：
He, Junyun;Hsuchou, Hung;Pan, Weihong
通讯作者：
Pan, Weihong
影响因子：
1.9
作者：
Pal, Rishi;Tiwari, Prafulla Chandra;Pant, Kamlesh Kumar
通讯作者：
Pant, Kamlesh Kumar
影响因子：
17.1
作者：
Iliff JJ;Wang M;Liao Y;Plogg BA;Peng W;Gundersen GA;Benveniste H;Vates GE;Deane R;Goldman SA;Nagelhus EA;Nedergaard M
通讯作者：
Nedergaard M
影响因子：
4.4
作者：
Jessen NA;Munk AS;Lundgaard I;Nedergaard M
通讯作者：
Nedergaard M