Association between chronic periodontal disease and obesity: a systematic review and meta-analysis.
Association between chronic periodontal disease and obesity: a systematic review and meta-analysis.
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DOI：
10.1902/jop.2010.100321
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发表时间：
2010-12
影响因子：
4.3
通讯作者：
Weston SJ
中科院分区：
文献类型：
--
作者：
Chaffee BW;Weston SJ
肥胖症的患病率正在增加，是导致全球发病率的主要因素。肥胖的一个后果可能是增加患牙周病的风险，尽管牙周炎可能反过来加剧代谢综合征，肥胖是其中的一个组成部分。本综述旨在从流行病学研究中系统地收集肥胖与牙周病关系的证据，并对这些疾病状态之间的关系进行量化总结。系统检索MEDLINE、SCOPUS、BIOSIS、LILACS、Cochrane图书馆和巴西牙科书目数据库，将相关研究的结果和特点提炼成标准化的形式。进行荟萃分析以获得关联性的汇总测量。电子搜索确定了554条独特的引文，70项研究符合先验纳入标准，代表57个独立的群体。几乎所有符合纳入标准的研究在设计上都是横断面的，41项研究的结果表明存在正相关。固定效应汇总优势比为1.35(肖尔校正的95%可信区间：1.23至1.47)，一些证据表明，在年轻人、女性和不吸烟者中发现了更强的相关性。额外的概要估计表明，肥胖个体的平均临床依恋丧失更大，牙周患者的平均体重指数(BMI)更高，并且随着BMI的增加，流行牙周疾病的几率有增加的趋势。尽管这些结果不太可能是偶然发现，但未经测量的混淆对这些估计产生了可信但未知的影响。这一正向关联与肥胖在牙周疾病发展中的生物学上可信的作用是一致和一致的。然而，由于很少有高质量的纵向研究，因此无法区分事件的时间顺序，从而限制了肥胖是牙周病的风险因素或牙周炎可能增加体重增加风险的证据。在临床实践中，肥胖的成年人应该有更高的牙周病患病率。
Obesity is increasing in prevalence and is a major contributor to worldwide morbidity. One consequence of obesity might be an increased risk for periodontal disease, although periodontal inflammation might, in turn, exacerbate the metabolic syndrome, of which obesity is one component. This review aims to systematically compile the evidence of an obesity–periodontal disease relationship from epidemiologic studies and to derive a quantitative summary of the association between these disease states. Systematic searches of the MEDLINE, SCOPUS, BIOSIS, LILACS, Cochrane Library, and Brazilian Bibliography of Dentistry databases were conducted with the results and characteristics of relevant studies abstracted to standardized forms. A meta-analysis was performed to obtain a summary measure of association. The electronic search identified 554 unique citations, and 70 studies met a priori inclusion criteria, representing 57 independent populations. Nearly all studies matching inclusion criteria were cross-sectional in design with the results of 41 studies suggesting a positive association. The fixed-effects summary odds ratio was 1.35 (Shore-corrected 95% confidence interval: 1.23 to 1.47), with some evidence of a stronger association found among younger adults, women, and non-smokers. Additional summary estimates suggested a greater mean clinical attachment loss among obese individuals, a higher mean body mass index (BMI) among periodontal patients, and a trend of increasing odds of prevalent periodontal disease with increasing BMI. Although these results are highly unlikely to be chance findings, unmeasured confounding had a credible but unknown influence on these estimates. This positive association was consistent and coherent with a biologically plausible role for obesity in the development of periodontal disease. However, with few quality longitudinal studies, there is an inability to distinguish the temporal ordering of events, thus limiting the evidence that obesity is a risk factor for periodontal disease or that periodontitis might increase the risk of weight gain. In clinical practice, a higher prevalence of periodontal disease should be expected among obese adults.
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影响因子：
4.3
作者：
Bouchard, Philippe;Boutouyrie, Pierre;Bourgeois, Denis
通讯作者：
Bourgeois, Denis
影响因子：
3.5
作者：
Ekuni, D.;Yamamoto, T.;Tobe, K.
通讯作者：
Tobe, K.
影响因子：
1.9
作者：
Duval, S;Tweedie, R
通讯作者：
Tweedie, R
影响因子：
7.6
作者：
Dietrich, T.;Kaye, E. Krall;Garcia, R. I.
通讯作者：
Garcia, R. I.
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N