Prenatal Exposure to Mercury, Manganese, and Lead and Adverse Birth Outcomes in Suriname: A Population-Based Birth Cohort Study.
Prenatal Exposure to Mercury, Manganese, and Lead and Adverse Birth Outcomes in Suriname: A Population-Based Birth Cohort Study.
复制标题
DOI：
10.3390/toxics10080464
复制
发表时间：
2022-08-11
期刊：
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
在全球范围内，不良分娩结果越来越多地与产前接触环境污染物（如汞、锰和铅）有关。本研究旨在评估苏里南380名孕妇产前接触汞、锰和铅与不良出生结局发生之间的关系。测定死产、早产、低出生体重和低阿普加评分的数量，以及血液中汞、锰、铅和相关协变量的水平。描述性统计使用频率分布计算。汞、锰和铅血水平与不良出生结局之间的关系，用列联表进行了探讨，用χ2检验（Fisher精确检验）进行了检验，并用p值表示。计算多元逻辑回归模型以探索独立关联，并以（校正）优势比（aOR）表示，95%置信区间（CI）。本研究的结果表明，血汞、锰或铅水平与死产、早产、低出生体重和低阿普加评分之间没有统计学上显著的关系。然而，协变量糖尿病（aOR 5.58, 95% CI(1.38-22.53)）与早产独立相关，协变量高血压（aOR 2.72, 95% CI(1.081-6.86)）与低出生体重独立相关。然而，观察到的孕妇血液中汞、锰和铅含量高于公共卫生关注的参考值的比例很高，因此有必要对不良分娩结果的风险因素进行环境卫生研究，以制定公共卫生政策干预措施，保护苏里南孕妇及其新生儿免受潜在的长期影响。
Globally, adverse birth outcomes are increasingly linked to prenatal exposure to environmental contaminants, such as mercury, manganese, and lead. This study aims to assess an association between prenatal exposure to mercury, manganese, and lead and the occurrence of adverse birth outcomes in 380 pregnant women in Suriname. The numbers of stillbirths, preterm births, low birth weights, and low Apgar scores were determined, as well as blood levels of mercury, manganese, lead, and relevant covariates. Descriptive statistics were calculated using frequency distributions. The associations between mercury, manganese, and lead blood levels, on the one hand, and adverse birth outcomes, on the other hand, were explored using contingency tables, tested with the χ2-test (Fisher’s exact test), and expressed with a p value. Multivariate logistic regression models were computed to explore independent associations and expressed as (adjusted) odds ratios (aOR) with 95% confidence intervals (CI). The findings of this study indicate no statistically significant relationship between blood mercury, manganese, or lead levels and stillbirth, preterm birth, low birth weight, and low Apgar score. However, the covariate diabetes mellitus (aOR 5.58, 95% CI (1.38–22.53)) was independently associated with preterm birth and the covariate hypertension (aOR 2.72, 95% CI (1.081–6.86)) with low birth weight. Nevertheless, the observed high proportions of pregnant women with blood levels of mercury, manganese, and lead above the reference levels values of public health concern warrants environmental health research on risk factors for adverse birth outcomes to develop public health policy interventions to protect pregnant Surinamese women and their newborns from potential long-term effects.
登录
查看更多内容
影响因子：
8.2
作者：
Crump, Casey;Sundquist, Jan;Sundquist, Kristina
通讯作者：
Sundquist, Kristina
DOI：
10.1016/j.ijheh.2018.05.015
发表时间：
2018-07-01
影响因子：
6
作者：
Ashley-Martin, Jillian;Dodds, Linda;Bouchard, Maryse F.
通讯作者：
Bouchard, Maryse F.
影响因子：
3.6
作者：
Aslam HM;Saleem S;Afzal R;Iqbal U;Saleem SM;Shaikh MW;Shahid N
通讯作者：
Shahid N
影响因子：
168.9
作者：
Blencowe, Hannah;Cousens, Simon;Lawn, Joy E.
通讯作者：
Lawn, Joy E.
影响因子：
3.1
作者：
Adane AA;Ayele TA;Ararsa LG;Bitew BD;Zeleke BM
通讯作者：
Zeleke BM