Heterogeneity in arterial remodeling among sublines of spontaneously hypertensive rats.
Heterogeneity in arterial remodeling among sublines of spontaneously hypertensive rats.
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DOI：
10.1371/journal.pone.0107998
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
VanBavel E
中科院分区：
文献类型：
--
作者：
Bakker EN;Groma G;Spijkers LJ;de Vos J;van Weert A;van Veen H;Everts V;Arribas SM;VanBavel E
自发性高血压大鼠（SHR）常被用作人类原发性高血压的模型。然而，SHR和其血压正常对照Wistar京都大鼠（WKY）均由遗传上不同的亚系组成。我们检验了高血压血管重构的病理生理学在大鼠亚系中不同的假设。我们研究了6周龄和5月龄的WKY和SHR的肠系膜阻力动脉。WKY和SHR亚系在血压、体重、血管重构、内皮功能和血管超微结构方面存在差异。SHR肠系膜小动脉的共同特征是壁厚、壁腔比和内弹性膜厚度增加。内皮功能障碍、血管硬化和肠系膜小动脉的向内重构不是高血压的常见特征，但具有亚线依赖性。遗传背景的差异与高血压大鼠不同类型的血管重构有关。
Spontaneously hypertensive rats (SHR) have been used frequently as a model for human essential hypertension. However, both the SHR and its normotensive control, the Wistar Kyoto rat (WKY), consist of genetically different sublines. We tested the hypothesis that the pathophysiology of vascular remodeling in hypertension differs among rat sublines. We studied mesenteric resistance arteries of WKY and SHR from three different sources, at 6 weeks and 5 months of age. Sublines of WKY and SHR showed differences in blood pressure, body weight, vascular remodeling, endothelial function, and vessel ultrastructure. Common features in small mesenteric arteries from SHR were an increase in wall thickness, wall-to-lumen ratio, and internal elastic lamina thickness. Endothelial dysfunction, vascular stiffening, and inward remodeling of small mesenteric arteries are not common features of hypertension, but are subline-dependent. Differences in genetic background associate with different types of vascular remodeling in hypertensive rats.
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影响因子：
4.9
作者：
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通讯作者：
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