Increased subcortical oligodendroglia‐like cells in pharmacoresistant focal epilepsy in children correlate with extensive epileptogenic zones
Increased subcortical oligodendroglia‐like cells in pharmacoresistant focal epilepsy in children correlate with extensive epileptogenic zones
复制标题
儿童耐药性局灶性癫痫中皮质下少突胶质细胞样细胞增多与广泛的致痫区相关
作者：
Satoru Sakuma;W. Halliday;Ruka Nomura;Shirou Baba;Yosuke Sato;K. Okanari;Midori Nakajima;E. Widjaja;C. Boelman;A. Ochi;O. Snead;J. Rutka;J. Drake;Steven P. Miller;H. Otsubo
与成人相比，癫痫手术中的皮质切除往往涉及儿童的多个叶，部分原因是潜在的病理学。在耐药性癫痫儿童的手术标本中观察到少突胶质细胞样细胞（OLC）。我们假设OLC在儿科药物耐药性局灶性癫痫中招募多叶致痫区。
Cortical resections in epilepsy surgery tend to involve multiple lobes in children, compared to adults, partly due to underlying pathology. Oligodendroglia‐like cells (OLCs) have been observed in surgical specimens from children with pharmacoresistant epilepsy. We hypothesize that OLCs recruit multiple‐lobe epileptogenic zones in pediatric pharmacoresistant focal epilepsy.
影响因子：
13.9
作者：
Kriegstein A;Alvarez-Buylla A
通讯作者：
Alvarez-Buylla A