The glial nature of embryonic and adult neural stem cells.
The glial nature of embryonic and adult neural stem cells.
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DOI：
10.1146/annurev.neuro.051508.135600
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发表时间：
2009
影响因子：
13.9
通讯作者：
Alvarez-Buylla A
中科院分区：
文献类型：
--
作者：
Kriegstein A;Alvarez-Buylla A
神经胶质细胞长期以来被认为是神经分化的最终产物，是与神经元起源非常不同的特化支持细胞。新的研究表明，一些神经胶质细胞-发育中的放射状胶质细胞（RG）和成年哺乳动物星形胶质细胞的特定亚群-具有初级祖细胞或神经干细胞（NSCs）的功能。这从根本上背离了经典观点，即在发育早期将神经元和胶质细胞谱系分开。神经干细胞行为的直接可视化和谱系追踪研究揭示了神经元谱系是如何出现的。在发育和成人大脑中，许多神经元和神经胶质细胞不是NSCs的直接后代，而是起源于转运扩增或中间祖细胞（IPCs）。在NSCs和IPCs中，遗传程序展现了中枢神经系统中产生非凡多样性的细胞类型。NSCs的发育时间和位置与它们的神经上皮来源密切相关，似乎是产生神经元类型的关键决定因素。鉴定NSCs和IPCs对于了解大脑发育和成人神经发生以及制定新的脑修复策略至关重要。
Glial cells were long considered end products of neural differentiation, specialized supportive cells with an origin very different from that of neurons. New studies have shown that some glial cells—radial glia (RG) in development and specific subpopulations of astrocytes in adult mammals—function as primary progenitors or neural stem cells (NSCs). This is a fundamental departure from classical views separating neuronal and glial lineages early in development. Direct visualization of the behavior of NSCs and lineage-tracing studies reveal how neuronal lineages emerge. In development and in the adult brain, many neurons and glial cells are not the direct progeny of NSCs, but instead originate from transit amplifying, or intermediate, progenitor cells (IPCs). Within NSCs and IPCs, genetic programs unfold for generating the extraordinary diversity of cell types in the central nervous system. The timing in development and location of NSCs, a property tightly linked to their neuroepithelial origin, appear to be the key determinants of the types of neurons generated. Identification of NSCs and IPCs is critical to understand brain development and adult neurogenesis and to develop new strategies for brain repair.
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DOI：
10.1007/bf01262651
发表时间：
1981-01-01
期刊：
JOURNAL OF NEUROCYTOLOGY
影响因子：
--
作者：
BRUCKNER, G;BIESOLD, D
通讯作者：
BIESOLD, D
影响因子：
2.5
作者：
ALTMAN, J;BAYER, SA
通讯作者：
BAYER, SA
影响因子：
64.5
作者：
CHENN, A;MCCONNELL, SK
通讯作者：
MCCONNELL, SK
影响因子：
5.3
作者：
ALTMAN, J;BAYER, SA
通讯作者：
BAYER, SA
DOI：
10.1073/pnas.0804558105
发表时间：
2008-09-02
影响因子：
11.1
作者：
Breunig, Joshua J.;Sarkisian, Matthew R.;Town, Terrence
通讯作者：
Town, Terrence