Frequent and Persistent Salivary Gland Ectasia and Oral Disease After COVID-19.
Frequent and Persistent Salivary Gland Ectasia and Oral Disease After COVID-19.
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DOI：
10.1177/0022034521997112
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发表时间：
2021-05
影响因子：
7.6
通讯作者：
Ciceri F
中科院分区：
文献类型：
--
作者：
Gherlone EF;Polizzi E;Tetè G;De Lorenzo R;Magnaghi C;Rovere Querini P;Ciceri F
2019冠状病毒病（COVID-19）在各种靶器官中的临床表现已得到广泛研究和描述。然而，对口腔受累的特征知之甚少。考虑到口腔粘膜和唾液腺细胞是已知的严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）直接复制的靶点，并且唾液中存在的病毒是感染的传播源，这是令人惊讶的。我们研究的目的是调查COVID-19幸存者口腔表现的存在和患病率。我们分析了2020年7月23日至2020年9月7日期间在意大利米兰一家单一转诊大学医院住院并随访的122名COVID-19幸存者的口腔受累情况，出院后的中位（四分位距）时间为104（95至132）天。我们发现口腔表现，特别是唾液腺扩张，出乎意料地常见，在83.9%的COVID-19幸存者中检测到口腔表现，而唾液腺扩张则占43%。唾液腺扩张反映了对SARS-CoV-2的高炎症反应，这与入院时的C反应蛋白（CRP）和乳酸脱氢酶（LDH）水平以及急性疾病期间抗生素的使用有显著关系。在多变量分析中，LDH水平和抗生素给药均作为唾液腺扩张的独立预测因子。颞下颌关节异常、面部疼痛和咀嚼肌无力也很常见。总体而言，这项针对COVID-19幸存者的回顾性和前瞻性队列研究显示，绝大多数患者的口腔残留损伤持续存在，远远超过临床恢复，并表明口腔是SARS-CoV-2感染的首选靶点。需要进一步的研究来阐明SARS-CoV-2感染和口腔疾病之间的联系。
The clinical picture of coronavirus disease 2019 (COVID-19) in various target organs has been extensively studied and described. However, relatively little is known about the characteristics of oral cavity involvement. This is surprising, considering that oral mucosal and salivary gland cells are known targets for the direct replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and that the presence of the virus in saliva is a source of transmission of the infection. The aim of our study was to investigate the presence and prevalence of oral manifestations in COVID-19 survivors. We profiled the oral involvement in 122 COVID-19 survivors that were hospitalized and followed up at a single-referral university hospital in Milan, Italy, between July 23, 2020 and September 7, 2020, after a median (interquartile range) time from hospital discharge of 104 (95 to 132) d. We found that oral manifestations, specifically salivary gland ectasia, were unexpectedly common, with oral manifestations being detected in 83.9% while salivary gland ectasia in 43% of COVID-19 survivors. Salivary gland ectasia reflected the hyperinflammatory response to SARS-CoV-2, as demonstrated by the significant relationship with C-reactive protein (CRP) and lactate dehydrogenase (LDH) levels at hospital admission, and with the use of antibiotics during acute disease. Both LDH levels and antibiotic administration survived as independent predictors of salivary gland ectasia at multivariable analysis. Temporomandibular joint abnormalities, facial pain, and masticatory muscle weakness were also common. Overall, this retrospective and prospective cohort study of COVID-19 survivors revealed that residual damage of the oral cavity persists in the vast majority of patients far beyond clinical recovery, and suggests that the oral cavity represents a preferential target for SARS-CoV-2 infection. Further studies are needed to clarify the connection between SARS-CoV-2 infection and oral disorders.
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DOI：
10.1038/nrmicro.2016.81
发表时间：
2016-08
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
de Wit E;van Doremalen N;Falzarano D;Munster VJ
通讯作者：
Munster VJ
影响因子：
3.7
作者：
De Lorenzo R;Conte C;Lanzani C;Benedetti F;Roveri L;Mazza MG;Brioni E;Giacalone G;Canti V;Sofia V;D'Amico M;Di Napoli D;Ambrosio A;Scarpellini P;Castagna A;Landoni G;Zangrillo A;Bosi E;Tresoldi M;Ciceri F;Rovere-Querini P
通讯作者：
Rovere-Querini P
影响因子：
3.8
作者：
Martin Carreras-Presas, Carmen;Amaro Sanchez, Juan;Somacarrera Perez, Maria Luisa
通讯作者：
Somacarrera Perez, Maria Luisa
影响因子：
1.3
作者：
Nayyar, Supreet Singh;Thiagarajan, Shivakumar;Prabhash, Kumar
通讯作者：
Prabhash, Kumar
影响因子：
24.8
作者：
Isho B;Abe KT;Zuo M;Jamal AJ;Rathod B;Wang JH;Li Z;Chao G;Rojas OL;Bang YM;Pu A;Christie-Holmes N;Gervais C;Ceccarelli D;Samavarchi-Tehrani P;Guvenc F;Budylowski P;Li A;Paterson A;Yue FY;Marin LM;Caldwell L;Wrana JL;Colwill K;Sicheri F;Mubareka S;Gray-Owen SD;Drews SJ;Siqueira WL;Barrios-Rodiles M;Ostrowski M;Rini JM;Durocher Y;McGeer AJ;Gommerman JL;Gingras AC
通讯作者：
Gingras AC