Methamphetamine and amphetamine derived from the metabolism of selegiline.
Methamphetamine and amphetamine derived from the metabolism of selegiline.
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甲基苯丙胺和安非他明源自司来吉兰的代谢。
DOI：
10.1520/jfs13885j
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发表时间：
1995
影响因子：
1.6
通讯作者：
Andre Greedan
中科院分区：
文献类型：
--
作者：
R. Romberg;S. B. Needleman;J. J. Snyder;Andre Greedan
常规甲基苯丙胺检测发现了一份筛查和确认结果不一致的尿样。甲基苯丙胺RIA筛选试验（诊断产品公司）表明为临界阳性样本，而非手性确证性GC/MS结果显示甲基苯丙胺为4690 ng/mL，苯丙胺为1895 ng/mL。用S（-）-N-三氟乙酰基脯氨酰氯衍生化后的样本分析显示仅存在1-苯丙胺和1-甲基苯丙胺。后来得知，提供标本的人一直在服用司来吉兰。司来吉兰，（-）丙炔甲基苯丙胺，是一种用于治疗帕金森病的单胺氧化酶抑制剂。它以商品名Eldepryl出售。其主要代谢产物为1-甲基苯丙胺、1-苯丙胺和N-去甲基司来吉兰。采集并分析其他司来吉兰使用者的尿液标本。注意到特征性代谢模式，例如1-甲基苯丙胺与1-苯丙胺的比例约为2.8。这与在摄入纯1-甲基苯丙胺的个体的尿液中观察到的情况相反，例如使用Vicks吸入器，其中尿液中的1-甲基苯丙胺与1-苯丙胺的比例通常大于8。在不使用手性鉴定技术解释甲基苯丙胺结果时，建议谨慎。
Routine methamphetamine testing identified a urine specimen with inconsistent screening and confirmation results. The methamphetamine RIA screening test (Diagnostic Products Corporation) indicated a borderline positive specimen, while the achiral confirmatory GC/MS result showed 4690 ng/mL of methamphetamine and 1895 ng/mL of amphetamine. Analysis of the specimen after derivatization with S(-)-N-trifluoroacetylprolyl chloride showed only the presence of 1-amphetamine and 1-methamphetamine. It was later learned that the individual providing the specimen had been taking Selegiline. Selegiline, (-) propynylmethamphetamine, is a monoamine oxidase inhibitor used for the treatment of Parkinson's disease. It is sold under the trade name Eldepryl. Its major metabolites are 1-methamphetamine, 1-amphetamine and N-desmethylselegiline. Urine specimens from other Selegiline users were obtained and analyzed. A characteristic metabolic pattern was noted, exemplified by a ratio of 1-methamphetamine to 1-amphetamine of about 2.8. This is in contrast to what is observed in the urine of individuals who ingest pure 1-methamphetamine, such as with Vicks Inhaler, where the 1-methamphetamine to 1-amphetamine ratio in the urine is usually greater than 8. Caution is advised when interpreting methamphetamine results without using a chiral identification technique.
影响因子：
2.5
作者：
FITZGERALD, RL;RAMOS, JM;POKLIS, A
通讯作者：
POKLIS, A