SnoN in regulation of embryonic development and tissue morphogenesis.

SnoN in regulation of embryonic development and tissue morphogenesis.
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DOI:
10.1016/j.febslet.2012.03.005
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发表时间:
2012-07-04
期刊:
影响因子:
3.5
通讯作者:
Luo K
Luo K
中科院分区:
生物学3区
文献类型:
--
作者:
Zhu Q;Luo K

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SnoN (Ski-novel protein)在胚胎发育、肿瘤发生和衰老过程中起重要作用。过去的研究主要集中在它在肿瘤发生中的作用。最近对其在小鼠模型和哺乳动物细胞中的表达模式和功能的研究表明,SnoN在不同的细胞水平上与多种信号分子相互作用,以组织环境和发育阶段依赖的方式调节几种信号通路的活性。这些研究表明,SnoN可能在胚胎发育和组织形态发生中具有广泛的功能。
SnoN (Ski-novel protein) plays an important role in embryonic development, tumorigenesis and aging. Past studies largely focused on its roles in tumorigenesis. Recent studies of its expression patterns and functions in mouse models and mammalian cells have revealed that SnoN interacts with multiple signaling molecules at different cellular levels to modulate the activities of several signaling pathways in a tissue context and developmental stage dependent manner. These studies suggest that SnoN may have broad functions in the embryonic development and tissue morphogenesis.
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