Food Availability Affects Orexin A/ Hypocretin-1-Induced Inhibition of Pulsatile Luteinizing Hormone Secretion in Female Rats
Food Availability Affects Orexin A/ Hypocretin-1-Induced Inhibition of Pulsatile Luteinizing Hormone Secretion in Female Rats
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食物供应量影响食欲素 A/Hypocretin-1 诱导的雌性大鼠脉动黄体激素分泌抑制
DOI：
10.1159/000257408
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发表时间：
2009
影响因子：
4.1
通讯作者：
T. Funabashi
中科院分区：
文献类型：
--
作者：
Miyako Furuta;D. Mitsushima;K. Shinohara;F. Kimura;T. Funabashi
Orexin A/hypocretin-1抑制雌性大鼠脉冲式黄体生成素（LH）分泌。在这项研究中，我们调查了这种抑制是否与禁食状态有关，正如我们以前的研究所建议的那样。我们首先研究了在血液采样期间，当食物可自由获取时，食欲素A是否抑制LH的脉动分泌。接下来，我们研究了静脉内施用葡萄糖（400 mg/kg）或乳酸（阴性对照; 400 mg/kg）对食欲素A诱导的脉冲式LH分泌抑制的影响。我们发现，食欲素A不影响脉冲LH分泌的存在下的食物，虽然它增加了摄食行为。当采血期间禁食时，注射食欲素A显著抑制LH的脉动分泌（p < 0.05）;静脉注射葡萄糖可迅速逆转这种抑制作用，但乳酸不能。由于食欲素A似乎没有影响脉冲LH分泌时，食物是随意提供的，我们推测，食欲素A有LH分泌的影响时，食欲素A诱导的饥饿伴随着压力，如没有食物。此外，葡萄糖和食物在促性腺激素释放激素脉冲产生中可能作为饱腹感因素。
Orexin A/hypocretin-1 inhibits pulsatile luteinizing hormone (LH) secretion in female rats. In this study, we investigated whether this inhibition was tied to the fasting state, as suggested by our previous study. We first examined whether orexin A inhibited pulsatile LH secretion when food was available ad libitumduring blood sampling. Next, we investigated the effect of intravenous administration of glucose (400 mg/kg) or lactic acid (negative control; 400 mg/kg) on orexin A-induced inhibition of pulsatile LH secretion. We found that orexin A did not affect pulsatile LH secretion in the presence of food, although it increased feeding behavior. Injection of orexin A significantly inhibited pulsatile LH secretion when food was withheld during blood sampling (p < 0.05); this inhibitory effect was rapidly reversed by intravenous injection of glucose but not lactic acid. Because orexin A did not seem to affect pulsatile LH secretion when food was available ad libitum, we speculate that orexin A has an effect on LH secretion when orexin A-induced hunger is accompanied by stress, such as the absence of food. Furthermore, glucose as well as food may act as a satiety factor in gonadotropin-releasing hormone pulse generation.
DOI：
10.1073/pnas.95.1.322
发表时间：
1998-01-06
影响因子：
11.1
作者：
De Lecea, L;Kilduff, TS;Sutcliffe, JG
通讯作者：
Sutcliffe, JG
影响因子：
4.8
作者：
Campbell, RE;Grove, KL;Smith, MS
通讯作者：
Smith, MS