Altered resting state brain networks in Parkinson's disease.
Altered resting state brain networks in Parkinson's disease.
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DOI：
10.1371/journal.pone.0077336
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Krämer UM
中科院分区：
文献类型：
--
作者：
Göttlich M;Münte TF;Heldmann M;Kasten M;Hagenah J;Krämer UM
帕金森病（PD）是一种神经退行性疾病，影响黑质中的多巴胺能神经元，导致皮质-纹状体-丘脑-皮质环功能障碍。除了特征性的运动症状外，PD患者还经常表现出认知障碍、情感变化和其他非运动症状，这表明对脑功能的系统性影响。在这里，我们使用功能性磁共振成像和基于图论的分析方法来研究PD患者（n = 37）与健康对照组（n = 20）相比全脑内在功能连接的改变。 全球网络特性表明，在PD的处理效率较低。对大脑网络模块的分析表明，感觉运动网络内的连通性增加，但视觉网络与其他大脑模块的相互作用减少。我们发现，主要是楔叶和腹侧尾状核，内侧眶额皮质和颞叶之间的连接较低。为了识别改变连接的区域，我们在ROI和整个大脑的体素水平上绘制了内在功能连接的程度。与健康对照组相比，PD患者的内侧和中眶额皮质的连通性较低。枕叶（楔叶和距状核）的连接程度也降低，但在上级顶叶皮层、后扣带回、缘上回和辅助运动区的连接程度增加。我们的研究结果的全球网络和模块的属性表明，PD表现为断开综合征。这在视觉网络模块中表现得最为明显。PD患者感觉运动模块内较高的连通性可能与补偿机制有关，以克服纹状体-皮层运动回路的功能缺陷或与脑网络之间的相互抑制的丧失有关。视觉网络的异常连接可能与运动功能改变引起的适应和补偿过程有关。我们的分析方法被证明是敏感的检测疾病相关的本地化的影响，以及在中间和全球范围内的网络功能的变化。
Parkinson’s disease (PD) is a neurodegenerative disorder affecting dopaminergic neurons in the substantia nigra leading to dysfunctional cortico-striato-thalamic-cortical loops. In addition to the characteristic motor symptoms, PD patients often show cognitive impairments, affective changes and other non-motor symptoms, suggesting system-wide effects on brain function. Here, we used functional magnetic resonance imaging and graph-theory based analysis methods to investigate altered whole-brain intrinsic functional connectivity in PD patients (n = 37) compared to healthy controls (n = 20). Global network properties indicated less efficient processing in PD. Analysis of brain network modules pointed to increased connectivity within the sensorimotor network, but decreased interaction of the visual network with other brain modules. We found lower connectivity mainly between the cuneus and the ventral caudate, medial orbitofrontal cortex and the temporal lobe. To identify regions of altered connectivity, we mapped the degree of intrinsic functional connectivity both on ROI- and on voxel-level across the brain. Compared to healthy controls, PD patients showed lower connectedness in the medial and middle orbitofrontal cortex. The degree of connectivity was also decreased in the occipital lobe (cuneus and calcarine), but increased in the superior parietal cortex, posterior cingulate gyrus, supramarginal gyrus and supplementary motor area. Our results on global network and module properties indicated that PD manifests as a disconnection syndrome. This was most apparent in the visual network module. The higher connectedness within the sensorimotor module in PD patients may be related to compensation mechanism in order to overcome the functional deficit of the striato-cortical motor loops or to loss of mutual inhibition between brain networks. Abnormal connectivity in the visual network may be related to adaptation and compensation processes as a consequence of altered motor function. Our analysis approach proved sensitive for detecting disease-related localized effects as well as changes in network functions on intermediate and global scale.
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DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
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通讯作者：
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