Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation.
Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation.
复制标题
真核进化和发育中凋亡蛋白的抑制剂:主题保护的模型。
DOI:
10.1016/j.devcel.2008.09.012
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发表时间:
2008-10
影响因子:
11.8
通讯作者:
Duckett, Colin S.
中科院分区:
文献类型:
--
作者:
O'Riordan, Mary X. D.;Bauler, Laura D.;Scott, Fiona L.;Duckett, Colin S.
The past decade and a half has witnessed the discovery of a large, evolutionarily conserved family of cellular genes bearing homology to the prototype baculovirus Inhibitor of Apoptosis (IAP). The logical decision in the field to also refer to these cellular proteins as IAPs fails to do justice to this versatile group of factors that play a wide range of roles in eukaryotic development and homeostasis which include, but are not limited to, the regulation of programmed cell death. Here we describe the shared functional characteristics of several well-characterized IAPs whose defining motifs place them more in the category of multifunctional modular protein interaction domains.
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影响因子:
11.8
作者:
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通讯作者:
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