Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation.

Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation.
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真核进化和发育中凋亡蛋白的抑制剂:主题保护的模型。

DOI:
10.1016/j.devcel.2008.09.012
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发表时间:
2008-10
期刊:
影响因子:
11.8
通讯作者:
Duckett, Colin S.
Duckett, Colin S.
中科院分区:
生物学1区
文献类型:
--
作者:
O'Riordan, Mary X. D.;Bauler, Laura D.;Scott, Fiona L.;Duckett, Colin S.

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在过去的十五年中,人们发现了一个大的、进化上保守的细胞基因家族,该家族与原型杆状病毒细胞凋亡抑制剂(IAP)具有同源性。本领域中也将这些细胞蛋白称为IAP的逻辑决定未能公正地对待这组在真核发育和稳态中发挥广泛作用的多功能因子,所述真核发育和稳态包括但不限于程序性细胞死亡的调节。在这里,我们描述了几个良好的特点IAP的定义图案将它们更多的多功能模块化蛋白质相互作用域的类别中的共享功能特性。
The past decade and a half has witnessed the discovery of a large, evolutionarily conserved family of cellular genes bearing homology to the prototype baculovirus Inhibitor of Apoptosis (IAP). The logical decision in the field to also refer to these cellular proteins as IAPs fails to do justice to this versatile group of factors that play a wide range of roles in eukaryotic development and homeostasis which include, but are not limited to, the regulation of programmed cell death. Here we describe the shared functional characteristics of several well-characterized IAPs whose defining motifs place them more in the category of multifunctional modular protein interaction domains.
DOI: 10.1016/s1534-5807(03)00120-5
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影响因子: 11.8
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