Impact of HIV-infection on human somatosensory processing, spontaneous cortical activity, and cortical thickness: A multimodal neuroimaging approach.
Impact of HIV-infection on human somatosensory processing, spontaneous cortical activity, and cortical thickness: A multimodal neuroimaging approach.
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DOI：
10.1002/hbm.25408
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发表时间：
2021-06-15
影响因子：
4.8
通讯作者：
Wilson TW
中科院分区：
文献类型：
--
作者：
Casagrande CC;Lew BJ;Taylor BK;Schantell M;O'Neill J;May PE;Swindells S;Wilson TW
HIV感染与大脑结构和功能的广泛改变有关，尽管很少有研究检查这些畸变是否共定位以及临床和认知指标相关的程度。我们使用神经振荡活动的高分辨率结构MRI（sMRI）和脑磁图（MEG）成像来检查躯体感觉系统中的这个问题。44名HIV（PWH）参与者和55名人口统计学匹配的未感染对照者在MEG期间完成了成对脉冲体感刺激范例，并接受了3 T sMRI。MEG数据被转换到时频域;使用波束形成器对显着的传感器水平响应进行成像。虚拟传感器的时间序列来自峰值响应。这些数据被用来计算反应幅度，感觉门控指标，和自发皮层活动功率。使用形态学方法处理T1加权sMRI数据，以获得整个大脑的皮质厚度值。根据这些，估计与峰值响应一致的组织的皮质厚度。我们的研究结果表明，PWH和控制表现出躯体感觉门控，自发性皮质活动明显更强的PWH内的左中央后回。有趣的是，在相同的组织中，PWH相对于对照组也具有显著降低的皮质厚度。随访分析表明，皮质厚度的减少与CD 4最低点显著相关，并介导了HIV与左侧中央后回内自发皮质活动之间的关系。这些数据表明，PWH有异常强烈的自发性皮质活动在左中央后回和这种升高的活动是由局部减少皮质灰质厚度。44名HIV（PWH）参与者和55名人口统计学匹配的未感染对照者在MEG期间完成了成对脉冲体感刺激范例，并接受了3 T sMRI。这些数据被用来计算反应幅度，感觉门控指标，和自发皮层活动功率。我们的研究结果表明，PWH和对照组表现出体感门控，自发性皮质活动明显强于PWH的左中央后回。有趣的是，在相同的组织中，PWH相对于对照组也具有显著降低的皮质厚度。
HIV‐infection has been associated with widespread alterations in brain structure and function, although few studies have examined whether such aberrations are co‐localized and the degree to which clinical and cognitive metrics are related. We examine this question in the somatosensory system using high‐resolution structural MRI (sMRI) and magnetoencephalographic (MEG) imaging of neural oscillatory activity. Forty‐four participants with HIV (PWH) and 55 demographically‐matched uninfected controls completed a paired‐pulse somatosensory stimulation paradigm during MEG and underwent 3T sMRI. MEG data were transformed into the time‐frequency domain; significant sensor level responses were imaged using a beamformer. Virtual sensor time series were derived from the peak responses. These data were used to compute response amplitude, sensory gating metrics, and spontaneous cortical activity power. The T1‐weighted sMRI data were processed using morphological methods to derive cortical thickness values across the brain. From these, the cortical thickness of the tissue coinciding with the peak response was estimated. Our findings indicated both PWH and control exhibit somatosensory gating, and that spontaneous cortical activity was significantly stronger in PWH within the left postcentral gyrus. Interestingly, within the same tissue, PWH also had significantly reduced cortical thickness relative to controls. Follow‐up analyses indicated that the reduction in cortical thickness was significantly correlated with CD4 nadir and mediated the relationship between HIV and spontaneous cortical activity within the left postcentral gyrus. These data indicate that PWH have abnormally strong spontaneous cortical activity in the left postcentral gyrus and such elevated activity is driven by locally reduced cortical gray matter thickness. Forty‐four participants with HIV (PWH) and 55 demographically‐matched uninfected controls completed a paired‐pulse somatosensory stimulation paradigm during MEG and underwent 3T sMRI. These data were used to compute response amplitude, sensory gating metrics, and spontaneous cortical activity power. Our findings indicated both PWH and controls exhibit somatosensory gating, and that spontaneous cortical activity was significantly stronger in PWH within the left postcentral gyrus. Interestingly, within the same tissue, PWH also had significantly reduced cortical thickness relative to controls.
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影响因子：
16
作者：
Gross AM;Jaeger PA;Kreisberg JF;Licon K;Jepsen KL;Khosroheidari M;Morsey BM;Swindells S;Shen H;Ng CT;Flagg K;Chen D;Zhang K;Fox HS;Ideker T
通讯作者：
Ideker T
影响因子：
9.9
作者：
Grant, Igor;Franklin, Donald R., Jr.;Heaton, Robert K.
通讯作者：
Heaton, Robert K.
影响因子：
3.2
作者：
Heaton, Robert K.;Franklin, Donald R.;Ellis, Ronald J.;McCutchan, J. Allen;Letendre, Scott L.;LeBlanc, Shannon;Corkran, Stephanie H.;Duarte, Nichole A.;Clifford, David B.;Woods, Steven P.;Collier, Ann C.;Marra, Christina M.;Morgello, Susan;Mindt, Monica Rivera;Taylor, Michael J.;Marcotte, Thomas D.;Atkinson, J. Hampton;Wolfson, Tanya;Gelman, Benjamin B.;McArthur, Justin C.;Simpson, David M.;Abramson, Ian;Gamst, Anthony;Fennema-Notestine, Christine;Jernigan, Terry L.;Wong, Joseph;Grant, Igor
通讯作者：
Grant, Igor
影响因子：
2
作者：
Cromwell, Howard C.;Mears, Ryan P.;Boutros, Nash N.
通讯作者：
Boutros, Nash N.
影响因子：
6.2
作者：
Chang, L.;Yakupov, R.;Ernst, T.
通讯作者：
Ernst, T.