Neutrophil phenotypes and functions in cancer: A consensus statement.
Neutrophil phenotypes and functions in cancer: A consensus statement.
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癌症中的神经元表型和功能：共识声明。
DOI：
10.1084/jem.20220011
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发表时间：
2022-06-06
期刊：
影响因子：
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中科院分区：
文献类型：
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作者：
人们越来越认识到中性粒细胞在癌症中的功能状态。Quail等人对恶性肿瘤背景下中性粒细胞异质性的调控机制提供了共识声明，并讨论了中性粒细胞研究中的争议和解决方案。中性粒细胞是感染和炎症的第一反应者，因此是先天免疫防御的重要组成部分。了解中性粒细胞在各种炎症环境下的行为，可以深入了解它们在无菌和感染性疾病中的作用；然而，中性粒细胞在癌症中的研究还比较年轻。在这里，我们总结了中性粒细胞在癌症进展中的不同作用的关键概念和当前的知识差距。我们讨论了中性粒细胞在癌症中的异质性来源，并提供了在成熟和激活中不同的中性粒细胞状态的命名建议。我们解决了文献中的差异，这些差异强调了实验室之间应该考虑的技术标准的需要。最后，我们回顾了中性粒细胞生物学和先天免疫在癌症中的新问题。总的来说，我们强调中性粒细胞是一个比以前认识到的更多样化的群体，它们在癌症中的作用可能为治疗癌症提供新的未开发的机会。
There is a growing appreciation for the vastness of neutrophil functional states in cancer. Quail et al. provide a consensus statement on mechanisms governing neutrophil heterogeneity in the context of malignancy and discuss controversies and solutions in neutrophil research. Neutrophils are the first responders to infection and inflammation and are thus a critical component of innate immune defense. Understanding the behavior of neutrophils as they act within various inflammatory contexts has provided insights into their role in sterile and infectious diseases; however, the field of neutrophils in cancer is comparatively young. Here, we summarize key concepts and current knowledge gaps related to the diverse roles of neutrophils throughout cancer progression. We discuss sources of neutrophil heterogeneity in cancer and provide recommendations on nomenclature for neutrophil states that are distinct in maturation and activation. We address discrepancies in the literature that highlight a need for technical standards that ought to be considered between laboratories. Finally, we review emerging questions in neutrophil biology and innate immunity in cancer. Overall, we emphasize that neutrophils are a more diverse population than previously appreciated and that their role in cancer may present novel unexplored opportunities to treat cancer.
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DOI：
10.1126/science.aao4227
发表时间：
2018-09-28
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
Albrengues J;Shields MA;Ng D;Park CG;Ambrico A;Poindexter ME;Upadhyay P;Uyeminami DL;Pommier A;Küttner V;Bružas E;Maiorino L;Bautista C;Carmona EM;Gimotty PA;Fearon DT;Chang K;Lyons SK;Pinkerton KE;Trotman LC;Goldberg MS;Yeh JT;Egeblad M
通讯作者：
Egeblad M
影响因子：
5.8
作者：
Barros-Becker F;Squirrell JM;Burke R;Chini J;Rindy J;Karim A;Eliceiri KW;Gibson A;Huttenlocher A
通讯作者：
Huttenlocher A
DOI：
10.1002/art.41796
发表时间：
2021-12
期刊：
Arthritis & rheumatology (Hoboken, N.J.)
影响因子：
--
作者：
Blanco LP;Wang X;Carlucci PM;Torres-Ruiz JJ;Romo-Tena J;Sun HW;Hafner M;Kaplan MJ
通讯作者：
Kaplan MJ
影响因子：
2.8
作者：
Ali, Mohammad;Jasmin, Shahana;Biswas, Subrata K.
通讯作者：
Biswas, Subrata K.
影响因子：
11.5
作者：
Alfaro, Carlos;Teijeira, Alvaro;Melero, Ignacio
通讯作者：
Melero, Ignacio