Failure of prostacyclin analog iloprost to sustain coronary blood flow after recombinant tissue-type plasminogen-induced thrombolysis in dogs.
Failure of prostacyclin analog iloprost to sustain coronary blood flow after recombinant tissue-type plasminogen-induced thrombolysis in dogs.
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重组组织型纤溶酶原诱导狗溶栓后，前列环素类似物伊洛前列素无法维持冠状动脉血流。
DOI：
10.1016/0002-8703(93)91041-c
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发表时间：
1993
影响因子：
4.8
通讯作者：
Mehta,JL
中科院分区：
文献类型：
--
作者：
Nichols,WW;Nicolini,FA;Khan,S;Saldeen,TG;Mehta,JL
用重组组织型纤溶酶原激活剂（TPA）恢复电诱导血栓形成犬的冠状动脉血流后，冠状动脉经常很快再闭塞。冠状动脉再闭塞与再灌注后冠状动脉内血小板的强烈原位活化和凝血酶的生成有关。为了确定有效的血小板抑制剂前列环素类似物伊洛前列素在预防冠状动脉再闭塞中的作用，在23只犬的冠状动脉左前降支中形成闭塞性血栓。TPA（1 mg/kg，20分钟内静脉注射）给药后，17只犬出现冠状动脉再流。建立复流后，10只犬给予生理盐水，7只犬给予伊洛前列素（4 μg/kg，40分钟）。在生理盐水治疗组中，10只犬中有8只在90分钟内发生冠状动脉再闭塞（再闭塞率80%）。在伊洛前列素治疗组中，7只犬中有5只冠状动脉再闭塞（再闭塞率71%;p= NS vs TPA单药）。TPA诱导溶栓后，给予生理盐水或伊洛前列素的犬冠状动脉峰值血流的幅度和血流持续时间相似。扫描电子显微镜检查显示，所有受检犬均存在残余血栓和血栓远端冠状动脉狭窄的外观。因此，在TPA诱导的犬血栓溶解后，无论动物用盐水或伊洛前列素治疗，残余血栓形成和冠状动脉狭窄继续发生。再流后给予伊洛前列素不能调节冠状动脉再闭塞的频率。
The coronary artery often reoccludes soon after the flow has been restored with recombinant tissue-type plasminogen activator (TPA) in dogs with electrically-induced thrombosis. The coronary artery reocclusion relates to intense in situ platelet activation and thrombin generation in the reperfused coronary artery. To determine the effect of a potent platelet inhibitor, the prostacyclin analog iloprost, in the prevention of coronary artery reocclusion, an occlusive thrombus was created in the left anterior descending coronary artery in 23 dogs. Coronary artery reflow occurred in 17 dogs after TPA (1 mg/kg over 20 minutes intravenously) administration. After the reflow was established, 10 dogs were given saline and 7 dogs were given iloprost (4 μg/kg over 40 minutes). In the saline-treated group, the coronary artery reoccluded in 8 of 10 dogs over 90 minutes (reocclusion rate 80%). In the iloprost-treated group, the coronary artery reoccluded in five of seven dogs (reocclusion rate 71%;p= NS vs TPA alone). The magnitude of peak coronary blood flow and duration of flow were similar in dogs given saline or iloprost after TPA-induced thrombolysis. Scanning electron microscopy showed residual thrombus and the appearance of coronary arterial narrowing distal to the thrombus in all dogs examined. Thus residual thrombus formation and coronary artery narrowing continue to occur after TPA-induced thrombolysis in dogs whether the animals are treated with saline or iloprost. Administration of iloprost after reflow does not modulate the frequency of coronary artery reocclusion.
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影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
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影响因子：
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作者：
E. Falk
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影响因子：
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作者：
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