Spiking Correlation Analysis of Synchronous Spikes Evoked by Acupuncture Mechanical Stimulus.
Spiking Correlation Analysis of Synchronous Spikes Evoked by Acupuncture Mechanical Stimulus.
复制标题
针刺机械刺激引起的同步尖峰的尖峰相关分析
DOI：
10.3389/fncom.2020.532193
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发表时间：
2020
影响因子：
3.2
通讯作者：
Wang J
中科院分区：
文献类型：
--
作者：
Qin Q;Liu YJ;Shan BN;Che YQ;Han CX;Qin YM;Wang J
针刺ST36穴位可以唤起感觉神经系统的反应，并转化为脊髓背根的输出电信号。不同针刺手法诱发的神经反应活动，尤其是同步棘波事件有显著差异。为了识别这些网络协作活动，我们分析了同步尖峰事件中潜在的尖峰相关性。本文采用对数线性模型来描述不同针灸手法引起的网络反应活动。然后利用状态空间模型和贝叶斯理论估计网络尖峰相关性。用两组仿真数据验证了估计算法和模型的拟合优度的有效性。此外，还利用仿真数据分析了尖峰相关和同步尖峰事件之间的关系。最后，我们使用这种方法来识别四种不同的针灸手法所引起的网络棘波相关。结果表明，加力手法(转体加力和提插加力)能引起三级峰相关，而减法(转体加力和提插加力)不能引起三阶相关。这就是为什么加强手法引起的同步尖峰比减少手法更丰富的主要原因。
Acupuncturing the ST36 acupoint can evoke the response of the sensory nervous system, which is translated into output electrical signals in the spinal dorsal root. Neural response activities, especially synchronous spike events, evoked by different acupuncture manipulations have remarkable differences. In order to identify these network collaborative activities, we analyze the underlying spike correlation in the synchronous spike event. In this paper, we adopt a log-linear model to describe network response activities evoked by different acupuncture manipulations. Then the state-space model and Bayesian theory are used to estimate network spike correlations. Two sets of simulation data are used to test the effectiveness of the estimation algorithm and the model goodness-of-fit. In addition, simulation data are also used to analyze the relationship between spike correlations and synchronous spike events. Finally, we use this method to identify network spike correlations evoked by four different acupuncture manipulations. Results show that reinforcing manipulations (twirling reinforcing and lifting-thrusting reinforcing) can evoke the third-order spike correlation but reducing manipulations (twirling reducing and lifting-thrusting reducing) does not. This is the main reason why synchronous spikes evoked by reinforcing manipulations are more abundant than reducing manipulations.
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