Associations of fibroblast growth factor-23 with markers of inflammation, insulin resistance and obesity in adults.
Associations of fibroblast growth factor-23 with markers of inflammation, insulin resistance and obesity in adults.
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DOI：
10.1371/journal.pone.0122885
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Gutiérrez OM
中科院分区：
文献类型：
--
作者：
Hanks LJ;Casazza K;Judd SE;Jenny NS;Gutiérrez OM
成纤维细胞生长因子-23（FGF23）升高是心血管疾病的既定标志物。伴随心血管健康下降的上升的根本原因尚不清楚。先前的研究表明，FGF23浓度与炎症和胰岛素抵抗的标志物有关，但由于关注慢性肾病（CKD）患者以及缺乏种族和性别多样性，这些研究受到限制。本研究的目的是在一个大的社区居住的成年人队列中研究FGF 23与炎症标志物、胰岛素抵抗和人体测量学的相关性。FGF23与炎症标志物[白细胞介素-6（IL-6）、IL-10、高敏C反应蛋白（hsCRP）]、胰岛素利用[胰岛素抵抗的稳态模型评估（HOMA-IR）]和人体测量学[BMI和腰围（WC）]的关联性在1，040名受试者随机选自卒中地理和种族差异原因（REGARDS）研究，这是一项针对≥ 45岁黑人和白色成人的全国性研究。检验了人种和CKD状态对效应的影响，并相应地分析了分层模型。中值FGF 23浓度为69.6 RU/ml（IQR：53.2，102.7）。FGF23的四分位数越高，IL-6、IL-10、hsCRP和Alcohol的平均浓度越高（P趋势均<0.001）。在粗分析中，在FGF23四分位数之间，HOMA-IR、脂联素浓度、BMI或WC没有显著差异。CKD显著改变了FGF23与炎性标志物、HOMA-IR、BMI和WC之间的关系（P均≤ 0.01）。在调整社会人口统计学和临床变量的线性回归模型中，在无CKD的个体中，FGF23与IL-6、hsCRP、IL-10、HOMA-IR、BMI和WC呈正相关，但在CKD个体中不相关。此外，无论CKD状态如何，FGF23均与BGN呈正相关。升高的FGF 23浓度可以被认为是具有正常肾功能的个体中代谢功能下降的生物标志物。
Elevated fibroblast growth factor-23 (FGF23) is an established marker of cardiovascular disease. The underlying reason(s) for the rise accompanying cardiovascular health decline are unclear. Prior studies have shown that FGF23 concentrations are associated with markers of inflammation and insulin resistance but they have been limited by a focus on persons with chronic kidney disease (CKD) and lack of race and sex diversity. The objective of this study was to examine the associations of FGF23 and markers of inflammation, insulin resistance, and anthropometrics in a large cohort of community-dwelling adults. Associations of FGF23 with markers of inflammation [interleukin-6 (IL-6), IL-10, high sensitivity-CRP (hsCRP)], insulin utilization [resistin, adiponectin, homeostatic model assessment of insulin resistance (HOMA-IR)] and anthropometrics [BMI and waist circumference (WC)] were examined cross-sectionally in a 1,040 participants randomly selected from the Reason for Geographic and Racial Differences in Stroke (REGARDS) Study, a national study of black and white adults ≥45 years. Effect modification by race and CKD status was tested, and stratified models were analyzed accordingly. Median FGF23 concentration was 69.6 RU/ml (IQR: 53.2, 102.7). Higher quartiles of FGF23 were associated with higher mean concentrations of IL-6, IL-10, hsCRP and resistin (P trend<0.001 for all). There were no significant differences in HOMA-IR, adiponectin concentrations, BMI, or WC across FGF23 quartiles in the crude analyses. CKD significantly modified the relationships between FGF23 and inflammatory markers, HOMA-IR, BMI and WC (P ≤ 0.01 for all). In linear regression models adjusted for sociodemographic and clinical variables, FGF23 was positively associated with IL-6, hsCRP, IL-10, HOMA-IR, BMI and WC in individuals without CKD, but not among individuals with CKD. Additionally, FGF23 was positively associated with resistin irrespective of CKD status. Elevated FGF23 concentrations may be considered a biomarker for decline in metabolic function among individuals with normal kidney function.
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影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
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