Incident low muscle mass is associated with greater lung disease and lower circulating leptin in a tobacco-exposed longitudinal cohort.
Incident low muscle mass is associated with greater lung disease and lower circulating leptin in a tobacco-exposed longitudinal cohort.
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DOI：
10.1186/s12931-023-02521-3
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发表时间：
2023-09-22
影响因子：
5.8
通讯作者：
中科院分区：
文献类型：
--
作者：
Muscle loss is prevalent in chronic obstructive pulmonary disease (COPD). Prior studies evaluating musculoskeletal dysfunction in COPD have focused on individuals with baseline low muscle mass. Currently, there is limited data evaluating clinical characteristics and outcomes associated with progression to incident low muscle mass in a tobacco-exposed cohort of individuals with baseline normal muscle mass. We evaluated 246 participants from a single-center longitudinal tobacco-exposed cohort with serial spirometry, thoracic imaging, dual energy x-ray absorptiometry (DXA) measurements, walk testing, and plasma adipokine measurements. DXA-derived fat free mass index (FFMI) and appendicular skeletal mass index (ASMI) were used as surrogates for muscle mass. Participants with incident low muscle mass (LM) at follow-up were characterized by FFMI < 18.4 kg/m2 in males and < 15.4 kg/m2 in females and/or ASMI < 7.25 kg/m2 in males and < 5.67 kg/m2 in females. Twenty-five (10%) participants progressed to incident low muscle mass at follow-up. At baseline, the LM subgroup had greater active smoking prevalence (60% v. 38%, p = 0.04), lower FFMI (17.8 ± 1.7 kg/m2 v. 19.7 ± 2.9 kg/m2, p = 0.002), lower ASMI (7.3 ± 0.9 kg/m2 v. 8.2 ± 1.2 kg/m2, p = 0.0003), and lower plasma leptin (14.9 ± 10.1 ng/mL v. 24.0 ± 20.9 ng/mL, p = 0.04). At follow-up, the LM subgroup had higher COPD prevalence (68% v. 43%, p = 0.02), lower FEV1/FVC (0.63 ± 0.12 v. 0.69 ± 0.12, p = 0.02), lower %DLco (66.5 ± 15.9% v. 73.9 ± 16.8%, p = 0.03), and higher annual rate of FFMI decline (-0.17 kg/m2/year v. -0.04 kg/m2/year, p = 0.006). There were no differences in age, gender distribution, pack years smoking history, or walk distance. We identified a subgroup of tobacco-exposed individuals with normal baseline muscle mass who progressed to incident DXA-derived low muscle mass. This subgroup demonstrated synchronous lung disease and persistently low circulating leptin levels. Our study suggests the importance of assessing for muscle loss in conjunction with lung function decline when evaluating individuals with tobacco exposure. The online version contains supplementary material available at 10.1186/s12931-023-02521-3.
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影响因子：
3.9
作者：
Hirano T;Doi K;Matsunaga K;Takahashi S;Donishi T;Suga K;Oishi K;Yasuda K;Mimura Y;Harada M;Suizu S;Murakawa K;Chikumoto A;Ohteru Y;Matsuda K;Uehara S;Hamada K;Ohata S;Murata Y;Yamaji Y;Asami-Noyama M;Edakuni N;Kakugawa T
通讯作者：
Kakugawa T
DOI：
10.1164/rccm.201410-1830pp
发表时间：
2015-03-15
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24.7
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通讯作者：
van Hees, Hieronymus W. H.
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影响因子：
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作者：
Mason, Stefanie E.;Moreta-Martinez, Rafael;Washko, George R.
通讯作者：
Washko, George R.
影响因子：
10
作者：
Mason SE;Moreta-Martinez R;Labaki WW;Strand M;Baraghoshi D;Regan EA;Bon J;San Jose Estepar R;Casaburi R;McDonald MN;Rossiter H;Make BJ;Dransfield MT;Han MK;Young KA;Kinney G;Hokanson JE;San Jose Estepar R;Washko GR;COPDGene Investigators;COPDGene® Investigators
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COPDGene® Investigators