Respiratory exacerbations are associated with muscle loss in current and former smokers.
Respiratory exacerbations are associated with muscle loss in current and former smokers.
复制标题
呼吸恶化与当前和既往吸烟者的肌肉损失相关。
DOI：
10.1136/thoraxjnl-2020-215999
复制
发表时间：
2021-06
期刊：
影响因子：
10
通讯作者：
COPDGene® Investigators
中科院分区：
文献类型：
--
作者：
Mason SE;Moreta-Martinez R;Labaki WW;Strand M;Baraghoshi D;Regan EA;Bon J;San Jose Estepar R;Casaburi R;McDonald MN;Rossiter H;Make BJ;Dransfield MT;Han MK;Young KA;Kinney G;Hokanson JE;San Jose Estepar R;Washko GR;COPDGene Investigators;COPDGene® Investigators
Muscle wasting is a recognised extra-pulmonary complication in chronic obstructive pulmonary disease and has been associated with increased risk of death. Acute respiratory exacerbations are associated with reduction of muscle function, but there is a paucity of data on their long-term effect. This study explores the relationship between acute respiratory exacerbations and long-term muscle loss using serial measurements of CT derived pectoralis muscle area (PMA). Participants were included from two prospective, longitudinal, observational, multicentre cohorts of ever-smokers with at least 10 pack-year history. The primary analysis included 1332 (of 2501) participants from Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) and 4384 (of 10 198) participants from Genetic Epidemiology of COPD (COPDGene) who had complete data from their baseline and follow-up visits. PMA was measured on chest CT scans at two timepoints. Self-reported exacerbation data were collected from participants in both studies through the use of periodic longitudinal surveys. Age-related and excess muscle loss over time. Age, sex, race and body mass index were associated with baseline PMA. Participants experienced age-related decline at the upper end of reported normal ranges. In ECLIPSE, the exacerbation rate over time was associated with an excess muscle area loss of 1.3% (95% CI 0.6 to 1.9, p<0.001) over 3 years and in COPDGene with an excess muscle area loss of 2.1% (95% CI 1.2 to 2.8, p<0.001) over 5 years. Excess muscle area decline was absent in 273 individuals who participated in pulmonary rehabilitation. Exacerbations are associated with accelerated skeletal muscle loss. Each annual exacerbation was associated with the equivalent of 6 months of age-expected decline in muscle mass. Ameliorating exacerbation-associated muscle loss represents an important therapeutic target.
登录
查看更多内容
影响因子：
6.7
作者：
Fermont JM;Mohan D;Fisk M;Bolton CE;Macnee W;Cockcroft JR;McEniery C;Fuld J;Cheriyan J;Tal-Singer R;Müllerova H;Wood AM;Wilkinson IB;Polkey MI;ERICA consortium
通讯作者：
ERICA consortium
影响因子：
3.7
作者：
Fermont, Jilles M.;Bolton, Charlotte E.;Mullerova, Hana
通讯作者：
Mullerova, Hana
影响因子：
10
作者：
Swallow, Elisabeth B.;Reyes, Diana;Polkey, Michael I.
通讯作者：
Polkey, Michael I.
影响因子：
105.7
作者：
Man, WDC;Polkey, MI;Moxham, J
通讯作者：
Moxham, J
影响因子：
10
作者：
Mason SE;Moreta-Martinez R;Labaki WW;Strand M;Baraghoshi D;Regan EA;Bon J;San Jose Estepar R;Casaburi R;McDonald MN;Rossiter H;Make BJ;Dransfield MT;Han MK;Young KA;Kinney G;Hokanson JE;San Jose Estepar R;Washko GR;COPDGene Investigators;COPDGene® Investigators
通讯作者：
COPDGene® Investigators