Anhedonia predicts poorer recovery among youth with selective serotonin reuptake inhibitor treatment-resistant depression.
Anhedonia predicts poorer recovery among youth with selective serotonin reuptake inhibitor treatment-resistant depression.
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Anhedonia预测，选择性5-羟色胺再摄取抑制剂耐药性抑郁症的青年的恢复较差。
DOI：
10.1016/j.jaac.2012.01.011
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发表时间：
2012-04
影响因子：
13.3
通讯作者：
Brent DA
中科院分区：
文献类型：
--
作者：
McMakin DL;Olino TM;Porta G;Dietz LJ;Emslie G;Clarke G;Wagner KD;Asarnow JR;Ryan ND;Birmaher B;Shamseddeen W;Mayes T;Kennard B;Spirito A;Keller M;Lynch FL;Dickerson JF;Brent DA
确定抑郁症的症状维度，预测接受第二步治疗的抗ssri治疗青少年的康复。青少年抗抑郁治疗（TORDIA）试验包括334名抗ssri治疗的青少年，随机分为药物转换组，或药物转换组加CBT组。本研究在基线上检查了五个已建立的症状维度（儿童抑郁评定量表-修订版），因为它们预测了24周急性和持续治疗后的恢复。两项指标分别为缓解时间和无抑郁天数。同时检查所有五个抑郁症状维度的多变量分析表明，快感缺乏症是唯一一个预测更长的缓解时间的维度，也是唯一一个预测更少的无抑郁天数的维度。此外，当快感缺乏症和cdrs总分同时进行评估时，快感缺乏症继续唯一地预测更长的缓解时间和更少的无抑郁天数。在治疗难治性抑郁青少年中，快感缺乏可能是一个重要的负面预后指标。需要进一步的研究来阐明快感缺乏症的神经行为基础，并在整体治疗抑郁症的背景下测试针对快感缺乏症的治疗方法。
To identify symptom dimensions of depression that predict recovery among SSRI-treatment resistant adolescents undergoing second-step treatment. The Treatment of Resistant Depression in Adolescents (TORDIA) trial included 334 SSRI-treatment resistant youth randomized to a medication switch, or a medication switch plus CBT. This study examined five established symptom dimensions (Child Depression Rating Scale-Revised) at baseline as they predicted recovery over 24 weeks of acute and continuation treatment. The two indices of recovery that were evaluated were time to remission and number of depression-free days. Multivariate analyses examining all five depression symptom dimensions simultaneously indicated that Anhedonia was the only dimension to predict a longer time to remission, and also the only dimension to predict fewer depression-free days. In addition, when Anhedonia and CDRS-total score were evaluated simultaneously, Anhedonia continued to uniquely predict longer time to remission and fewer depression-free days. Anhedonia may represent an important negative prognostic indicator among treatment resistant depressed adolescents. Further research is needed to elucidate neurobehavioral underpinnings of anhedonia, and to test treatments that target anhedonia in the context of overall treatment of depression.
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DOI：
10.1176/appi.ajp.2008.08081201
发表时间：
2009-06
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Pizzagalli DA;Holmes AJ;Dillon DG;Goetz EL;Birk JL;Bogdan R;Dougherty DD;Iosifescu DV;Rauch SL;Fava M
通讯作者：
Fava M
DOI：
10.1097/chi.0b013e3181bef6e8
发表时间：
2009-12
影响因子：
13.3
作者：
Goldstein BI;Shamseddeen W;Spirito A;Emslie G;Clarke G;Wagner KD;Asarnow JR;Vitiello B;Ryan N;Birmaher B;Mayes T;Onorato M;Zelazny J;Brent DA
通讯作者：
Brent DA
影响因子：
5.9
作者：
Kennard, Betsy D.;Clarke, Greg N.;Brent, David A.
通讯作者：
Brent, David A.
影响因子：
17.7
作者：
Domino, Marisa Elena;Burns, Barbara J.;March, John S.
通讯作者：
March, John S.
影响因子：
7.6
作者：
Larsen, JT;McGraw, AP;Cacioppo, JT
通讯作者：
Cacioppo, JT