Physiology, injury, and recovery of interstitial cells of Cajal: basic and clinical science.
Physiology, injury, and recovery of interstitial cells of Cajal: basic and clinical science.
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DOI：
10.1053/j.gastro.2009.09.023
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发表时间：
2009-11
期刊：
影响因子：
29.4
通讯作者：
Farrugia G
中科院分区：
文献类型：
--
作者：
Huizinga JD;Zarate N;Farrugia G
在过去 15 年中，我们发现正常的胃肠运动需要卡哈尔间质细胞 (ICC)，从而不可逆转地改变了我们对胃肠功能细胞基础的理解。在这段相对较短的时间内的研究已经改变了我们最初的概念，即控制运动的核心单位是由神经和平滑肌组成，现在包括 ICC。这一概念现已扩展到胃肠道之外，表明它可能是调节需要节律性收缩的平滑肌功能的基本特性。 ICC分布于整个胃肠道，对控制胃肠运动具有重要功能，在疾病状态下常出现异常。最近，我们对 ICC 生理学以及损伤和恢复机制的理解取得了重大进展。这些进展将是本次审查的重点。
In the last 15 years, our understanding of the cellular basis of gastrointestinal function has been altered irreversibly by the discovery that normal gastrointestinal motility requires interstitial cells of Cajal (ICC). Research in this relatively short time period has modified our original concept that the core unit that controls motility is made up of nerves and smooth muscle, to one that now includes ICC. This concept has now expanded to beyond the gastrointestinal tract, suggesting that it may be a fundamental property of the regulation of smooth muscle function that requires rhythmic contraction. ICC are distributed throughout the gastrointestinal tract, have important functions in the control of gastrointestinal motility and are often abnormal in diseased states. Recently, significant steps forward have been made in our understanding of the physiology of ICC as well as mechanisms of injury and recovery. These advances will be the focus of this review.
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影响因子：
3.5
作者：
Gibbons SJ;De Giorgio R;Faussone Pellegrini MS;Garrity-Park MM;Miller SM;Schmalz PF;Young-Fadok TM;Larson DW;Dozois EJ;Camilleri M;Stanghellini V;Szurszewski JH;Farrugia G
通讯作者：
Farrugia G
影响因子：
2.5
作者：
Beckett, EAH;Takeda, Y;Ward, SM
通讯作者：
Ward, SM
影响因子：
29.4
作者：
Huizinga, JD;Berezin, I;Jacobson, K
通讯作者：
Jacobson, K
影响因子：
5.5
作者：
Hirst, GDS;Garcia-Londoño, AP;Edwards, FR
通讯作者：
Edwards, FR
影响因子：
2.5
作者：
Beckett, Elizabeth A. H.;Ro, Seungil;Ward, Sean M.
通讯作者：
Ward, Sean M.