Nucleotide sequence analysis of human T‐cell lymphotropic virus type I pX and LTR regions from patients with Sicca syndrome
Nucleotide sequence analysis of human T‐cell lymphotropic virus type I pX and LTR regions from patients with Sicca syndrome
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Sicca 综合征患者 I 型嗜 T 细胞淋巴细胞病毒 pX 和 LTR 区域的核苷酸序列分析
DOI：
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发表时间：
1999
影响因子：
12.7
通讯作者：
G. Agius
中科院分区：
文献类型：
--
作者：
A. Beby‐Defaux;François Frugier;A. Bourgoin;D. Moynet;C. Hajjar;S. Sainte;B. Guillemain;G. Agius
人类T细胞嗜淋巴细胞病毒I型（HTLV-I）与成人T细胞白血病（ATL）和热带痉挛性下肢轻瘫/HTLV-I相关性脊髓病（TSP/HAM）相关。其他炎症性疾病可能发生在HTLV‐I感染的患者中，例如类似于干燥综合征的干燥综合征。干燥综合征可能是HTLV‐I感染的独特临床表现，但经常与TSP/HAM相关，这可能表明干燥综合征可能是某些病例中疾病进展为TSP/HAM的早期事件。我们研究了特殊的pX和LTR突变是否与干燥综合征有关，或者可能认为存在TSP/HAM的临床进展。对来自患有干燥综合征（伴或不伴TSP/HAM）的加勒比患者、ATL患者和健康携带者的pX（特别是对应于Tax细胞毒性T淋巴细胞表位的pXI、pXII和pXIV ORF）和LTR区域进行测序。将序列与ATK-1原型和已发表的序列进行比对和比较。LTR序列与ATK-1的差异为1.5-2.4%。pX测序区域显示p12 I编码序列内的同源性较低。在功能重要区域内仅发现少数突变，但与临床状态无关。最后，没有发现可能与干燥综合征相关的突变或证明存在临床进展为TSP/HAM的突变。研究HTLV‐ I干燥综合征患者的临床演变以及确定不同阶段外周血和唾液腺中的HTLV‐I序列将是有意义的。J. Med. Virol. 59：245-255，1999.© 1999 Wiley利斯公司
Human T‐cell lymphotropic virus type I (HTLV‐I) is associated with adult T‐cell leukemia (ATL) and tropical spastic paraparesis/HTLV‐I‐associated myelopathy (TSP/HAM). Other inflammatory disorders may occur in HTLV‐I‐infected patients, such as sicca syndrome resembling Sjögren's syndrome. The sicca syndrome may be the unique clinical manifestation of HTLV‐I infection, but is associated frequently with TSP/HAM, which could suggest that sicca syndrome might be an early event in disease progression to TSP/HAM in some cases. We investigated whether peculiar pX and LTR mutations could be related to sicca syndrome, or might argue the existence of clinical progression to TSP/HAM. pX, especially pXI, pXII, and pXIV ORFs corresponding to Tax cytotoxic T‐lymphocyte epitopes, and LTR regions from Caribbean patients who have sicca syndrome with or without TSP/HAM, ATL patients, and healthy carriers were sequenced. The sequences were aligned and compared with ATK‐1 prototype and published sequences. LTR sequences exhibited 1.5–2.4% of divergence with ATK‐1. pX‐sequenced regions showed a lower homology within p12I encoding sequences. Only few mutations were found within functionally important regions, but were not associated specifically with the clinical status. Finally, no mutations that could be related to sicca syndrome or argue the existence of clinical progression to TSP/HAM were found. It would be of interest to study the clinical evolution of HTLV‐I–sicca syndrome in patients and to determine HTLV‐I sequences from peripheral blood and salivary glands at different stages. J. Med. Virol. 59:245–255, 1999. © 1999 Wiley‐Liss, Inc.
ATF2 和 CREB 与人类 T 细胞白血病病毒 1 型 LTR R 区结合的序列要求。
DOI：
10.1006/viro.1996.0205
发表时间：
1996
期刊：
Virology.
影响因子：
--
作者：
Xu,X;Kang,SH;Heidenreich,O;Brown,DA;Nerenberg,MI
通讯作者：
Nerenberg,MI
不同地理来源的人类 T 淋巴细胞病毒 1 型分离株的核苷酸序列分析。
影响因子：
1.5
作者：
Ratner,L;Philpott,T;Trowbridge,DB
通讯作者：
Trowbridge,DB
通过聚合酶链反应检测和表征 HTLV-I 非流行区域中人类 T 细胞嗜淋巴细胞病毒 I 型 (HTLV-I) 相关 T 细胞肿瘤。
影响因子：
20.3
作者：
Chadburn,A;Athan,E;Wieczorek,R;Knowles,DM
通讯作者：
Knowles,DM