The function of non-coding RNAs in genomic imprinting.
The function of non-coding RNAs in genomic imprinting.
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DOI:
10.1242/dev.030403
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发表时间:
2009-06
期刊:
影响因子:
--
通讯作者:
Barlow DP
中科院分区:
文献类型:
--
作者:
Koerner MV;Pauler FM;Huang R;Barlow DP
Non-coding RNAs (ncRNAs) that regulate gene expression in cis or in trans are a shared feature of prokaryotic and eukaryotic genomes. In mammals, cis-acting functions are associated with macro ncRNAs, which can be several hundred thousand nucleotides long. Imprinted ncRNAs are well-studied macro ncRNAs that have cis-regulatory effects on multiple flanking genes. Recent advances indicate that they employ different downstream mechanisms to regulate gene expression in embryonic and placental tissues. A better understanding of these downstream mechanisms will help to improve our general understanding of the function of ncRNAs throughout the genome.
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