The function of non-coding RNAs in genomic imprinting.

The function of non-coding RNAs in genomic imprinting.
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DOI:
10.1242/dev.030403
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发表时间:
2009-06
期刊:
Development (Cambridge, England)
影响因子:
--
通讯作者:
Barlow DP
Barlow DP
中科院分区:
其他
文献类型:
--
作者:
Koerner MV;Pauler FM;Huang R;Barlow DP

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以顺式或反式调节基因表达的非编码RNA(ncRNA)是原核和真核基因组的共同特征。在哺乳动物中,顺式作用功能与宏ncRNA相关,其可以是几十万个核苷酸长。印迹ncRNA是研究得很好的宏ncRNA,其对多个侧翼基因具有顺式调节作用。最近的进展表明,它们采用不同的下游机制来调节胚胎和胎盘组织中的基因表达。更好地理解这些下游机制将有助于提高我们对整个基因组中ncRNA功能的总体理解。
Non-coding RNAs (ncRNAs) that regulate gene expression in cis or in trans are a shared feature of prokaryotic and eukaryotic genomes. In mammals, cis-acting functions are associated with macro ncRNAs, which can be several hundred thousand nucleotides long. Imprinted ncRNAs are well-studied macro ncRNAs that have cis-regulatory effects on multiple flanking genes. Recent advances indicate that they employ different downstream mechanisms to regulate gene expression in embryonic and placental tissues. A better understanding of these downstream mechanisms will help to improve our general understanding of the function of ncRNAs throughout the genome.
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