Childhood-Onset Myasthenia Gravis Patients Benefited from Thymectomy in a Long-Term Follow-up Observation.
Childhood-Onset Myasthenia Gravis Patients Benefited from Thymectomy in a Long-Term Follow-up Observation.
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在长期随访观察中，儿童期重症肌无力患者受益于胸腺切除术
DOI：
10.1055/s-0042-1744150
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发表时间：
2022-12
影响因子：
1.8
通讯作者：
Bu, Bitao
中科院分区：
文献类型：
--
作者：
Zhang, Qing;Cao, Yayun;Bi, Zhuajin;Ma, Xue;Yang, Mengge;Gao, Huajie;Gui, Mengcui;Bu, Bitao
简介 胸腺切除术对治疗儿童期重症肌无力 (CMG) 的效果仍存在争议。本研究的目的是评估 CMG 患者胸腺切除术的临床结果和相关预后因素。 材料与方法 本回顾性研究共纳入 32 名 18 岁之前接受胸腺切除术的 CMG 患者。通过量化重症肌无力 (QMG) 评分、重症肌无力相关日常生活活动 (MG-ADL) 评分以及美国重症肌无力基金会干预后状态来评估胸腺切除术后的临床状态。重复测量方差分析 (ANOVA) 检查了 5 年随访期间术后评分的变化。应用单变量逻辑回归来确定与短期（术后 1 年）和长期（术后 5 年）临床结果相关的因素。 结果 重复测量方差分析显示，QMG 评分（F = 6.737，p < 0.001）和 MG-ADL 评分（F = 7.923，p < 0.001）随时间逐渐下降。术前持续时间（比值比 [OR] = 0.85，95% 置信区间 [CI]：0.73–1.00，p = 0.043）、性别（OR = 0.19，95% CI：0.04–0.94，p = 0.041）和 MG 亚组（OR = 13.33，95% CI：1.43–123.99，p = 0.023）是术后 1 年预后的预测因子。较短的病程（OR = 0.82，95% CI：0.70–0.97，p = 0.018）和广义CMG（OR = 6.11，95% CI：1.06–35.35，p = 0.043）被发现具有更有利的长期结果。 结论 我们的结果表明胸腺切除术可有效治疗 CMG。对于 CMG 患者，尤其是处于 GMG 早期病程的患者，可以推荐胸腺切除术。
Introduction The effect of thymectomy on the treatment of childhood-onset myasthenia gravis (CMG) remains debatable. The objective of this study was to evaluate the clinical outcome and relevant prognostic factors of thymectomy for CMG patients. Materials and Methods A total of 32 CMG patients who underwent thymectomy before 18 years of age were included in this retrospective study. Clinical state following thymectomy was assessed by quantified myasthenia gravis (QMG) scores, myasthenia gravis–related activities of daily living (MG-ADL) scores, and Myasthenia Gravis Foundation of America postintervention status. Repeated-measures analysis of variance (ANOVA) examined the changes in postoperative scores during the 5-year follow-up. Univariate logistic regression was applied to identify factors associated with short-term (1-year postoperation) and long-term (5-year postoperation) clinical outcomes. Results Repeated-measures ANOVA showed that QMG scores ( F = 6.737, p < 0.001) and MG-ADL scores ( F = 7.923, p < 0.001) decreased gradually with time. Preoperative duration (odds ratio [OR] = 0.85, 95% confidence interval [CI]: 0.73–1.00, p = 0.043), gender (OR = 0.19, 95% CI: 0.04–0.94, p = 0.041), and MG subgroup (OR = 13.33, 95% CI: 1.43–123.99, p = 0.023) were predictors for 1-year postoperative prognosis. Shorter disease duration (OR = 0.82, 95% CI: 0.70–0.97, p = 0.018) and generalized CMG (OR = 6.11, 95% CI: 1.06–35.35, p = 0.043) were found to have more favorable long-term results. Conclusion Our results suggest that thymectomy is effective in treating CMG. Thymectomy could be recommended for CMG patients, especially for patients in the early course of GMG.
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影响因子：
2.4
作者：
Derderian, S. Christopher;Potter, D. Dean;Partrick, David A.
通讯作者：
Partrick, David A.
影响因子：
4.6
作者：
Endo, S;Yamaguchi, T;Sohara, Y
通讯作者：
Sohara, Y
影响因子：
3.4
作者：
Essa, M;El-Medany, Y;Al-Kattan, K
通讯作者：
Al-Kattan, K
影响因子：
3.5
作者：
Huang, CS;Hsu, HS;Huang, MH
通讯作者：
Huang, MH
DOI：
10.1016/s0022-5223(96)70264-7
发表时间：
1996-08-01
影响因子：
6
作者：
Nakamura, H;Taniguchi, Y;Mori, T
通讯作者：
Mori, T