The transcriptomic signature of the aging podocyte.

The transcriptomic signature of the aging podocyte.
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DOI:
10.1016/j.kint.2020.08.004
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发表时间:
2020-11
影响因子:
19.6
通讯作者:
Susztak, Katalin
Susztak, Katalin
中科院分区:
医学1区
文献类型:
--
作者:
Mukhi, Dhanunjay;Susztak, Katalin

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衰老是慢性肾脏疾病最强的独立危险因素。肾小球上皮细胞不能增殖,更新能力有限;因此,足细胞必须维持一种微妙的细胞内稳态,使它们能够发挥作用并适应人类一生中承受的压力。在这里,Wang等人对衰老足细胞进行了无偏倚的转录组学分析,并确定了重要的新调控因子。
Aging is the strongest independent risk factor for chronic kidney disease. Glomerular epithelial cells are unable to proliferate and have limited ability to renew; therefore, podocytes must maintain a delicate intracellular homeostasis that enables them to function and adapt to stress endured during the human life span. Here, Wang et al. performed unbiased transcriptomic analysis of aging podocytes and identified important novel regulators.
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