Health Benefits of Coffee Consumption for Cancer and Other Diseases and Mechanisms of Action.
Health Benefits of Coffee Consumption for Cancer and Other Diseases and Mechanisms of Action.
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DOI：
10.3390/ijms24032706
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发表时间：
2023-01-31
影响因子：
5.6
通讯作者：
Chapkin, Robert S.
中科院分区：
文献类型：
--
作者：
Safe, Stephen;Kothari, Jainish;Hailemariam, Amanuel;Upadhyay, Srijana;Davidson, Laurie A.;Chapkin, Robert S.
咖啡是世界上消费最广泛的饮料之一，流行病学研究表明，咖啡消费量的增加与死亡率的降低以及神经和代谢性疾病(包括帕金森氏症和2型糖尿病)发病率的降低有关。此外，也有证据表明，较高的咖啡消费量与较低的结肠癌和直肠癌以及乳腺癌、子宫内膜癌和其他癌症的发病率有关，尽管对于其中一些癌症，结果是相互矛盾的。这些研究反映了咖啡的化学预防作用；也有证据表明，饮用咖啡可能对某些形式的乳腺癌和结肠癌有治疗作用，这需要进一步调查。烘焙咖啡中1000多种化合物的化学预防或化学治疗作用的机制是复杂的，可能会因不同的疾病而异。其中一些机制可能与核因子红系2(NRF2)调节的以氧化应激为靶点的通路或诱导活性氧物种杀死病变细胞的通路(主要是治疗性的)有关。有证据表明，包括芳香烃受体(AhR)和孤儿核受体4A1(NR4A1)在内的受体参与，以及表观遗传途径和肠道微生物群的贡献。进一步阐明这些机制将有助于咖啡提取物未来用于治疗癌症和其他炎症性疾病的潜在临床应用。
Coffee is one of the most widely consumed beverages worldwide, and epidemiology studies associate higher coffee consumption with decreased rates of mortality and decreased rates of neurological and metabolic diseases, including Parkinson’s disease and type 2 diabetes. In addition, there is also evidence that higher coffee consumption is associated with lower rates of colon and rectal cancer, as well as breast, endometrial, and other cancers, although for some of these cancers, the results are conflicting. These studies reflect the chemopreventive effects of coffee; there is also evidence that coffee consumption may be therapeutic for some forms of breast and colon cancer, and this needs to be further investigated. The mechanisms associated with the chemopreventive or chemotherapeutic effects of over 1000 individual compounds in roasted coffee are complex and may vary with different diseases. Some of these mechanisms may be related to nuclear factor erythroid 2 (Nrf2)-regulated pathways that target oxidative stress or pathways that induce reactive oxygen species to kill diseased cells (primarily therapeutic). There is evidence for the involvement of receptors which include the aryl hydrocarbon receptor (AhR) and orphan nuclear receptor 4A1 (NR4A1), as well as contributions from epigenetic pathways and the gut microbiome. Further elucidation of the mechanisms will facilitate the potential future clinical applications of coffee extracts for treating cancer and other inflammatory diseases.
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影响因子：
5.2
作者：
Chapkin RS;Davidson LA;Park H;Jin UH;Fan YY;Cheng Y;Hensel ME;Landrock KK;Allred C;Menon R;Klemashevich C;Jayaraman A;Safe S
通讯作者：
Safe S
影响因子：
9.3
作者：
Chen, Yanchun;Zhang, Yuan;Zhang, Mengnan;Yang, Hongxi;Wang, Yaogang
通讯作者：
Wang, Yaogang
影响因子：
3.1
作者：
Cohen, Aaron B.;Lee, Dale;Long, Millie D.;Kappelman, Michael D.;Martin, Christopher F.;Sandler, Robert S.;Lewis, James D.
通讯作者：
Lewis, James D.
影响因子：
3.7
作者：
Deng, Yuqing;Wu, Tingting;Luo, Gang;Chen, Lin
通讯作者：
Chen, Lin
DOI：
10.3390/antiox11020379
发表时间：
2022-02-14
期刊：
Antioxidants (Basel, Switzerland)
影响因子：
--
作者：
Barré T;Fontaine H;Pol S;Ramier C;Di Beo V;Protopopescu C;Marcellin F;Bureau M;Bourlière M;Dorival C;Petrov-Sanchez V;Asselah T;Delarocque-Astagneau E;Larrey D;Duclos-Vallée JC;Carrat F;Carrieri P;On Behalf Of The Anrs/Afef Hepather Study Group
通讯作者：
On Behalf Of The Anrs/Afef Hepather Study Group