Metabolic Disorders in Patients with Chronic Hepatitis B Virus Infection: Coffee as a Panacea? (ANRS CO22 Hepather Cohort).
Metabolic Disorders in Patients with Chronic Hepatitis B Virus Infection: Coffee as a Panacea? (ANRS CO22 Hepather Cohort).
复制标题
DOI：
10.3390/antiox11020379
复制
发表时间：
2022-02-14
期刊：
影响因子：
--
通讯作者：
On Behalf Of The Anrs/Afef Hepather Study Group
中科院分区：
文献类型：
--
作者：
Barré T;Fontaine H;Pol S;Ramier C;Di Beo V;Protopopescu C;Marcellin F;Bureau M;Bourlière M;Dorival C;Petrov-Sanchez V;Asselah T;Delarocque-Astagneau E;Larrey D;Duclos-Vallée JC;Carrat F;Carrieri P;On Behalf Of The Anrs/Afef Hepather Study Group
慢性乙型肝炎病毒（HBV）感染者肝病进展的风险较高，这与代谢紊乱呈正相关，但与血脂异常呈负相关。饮食，包括饮食抗氧化剂，是代谢紊乱管理的一个杠杆。特别是，在普通人群中，咖啡摄入量的增加与不同的代谢结果有关。我们的目的是测试这种关联是否发生在hbv感染者中。基于ANRS CO22 Hepather队列的横断面数据，我们以(i)血脂异常、（ii）高血压和（iii）糖尿病为结局，并以人口统计学、临床和社会行为（包括咖啡消费）数据为解释变量，建立了logistic回归模型。在4746例hbv感染患者中，每天饮用≥3杯咖啡与血脂异常的高风险相关（校正优势比[95%置信区间]1.49 [1.10-2.00],p = 0.009），高血压的风险较低（0.64 [0.50-0.82],p = 0.001）。它与糖尿病无关。在hbv感染患者中，高咖啡摄入量与高血脂异常风险和低高血压风险相关，这两种影响预计与良好的临床结果相关。进一步的研究应该测试这种代谢益处是否转化为该人群死亡风险的降低。
People living with chronic hepatitis B virus (HBV) infection are at high risk of liver disease progression, which is positively associated with metabolic disorders, but inversely associated with dyslipidemia. Diet, including dietary antioxidants, is a lever of metabolic disorder management. In particular, elevated coffee consumption is associated with different metabolic outcomes in the general population. We aimed to test whether such associations occur in HBV-infected people. Based on cross-sectional data from the ANRS CO22 Hepather cohort, we performed logistic regression models with (i) dyslipidemia, (ii) hypertension, and (iii) diabetes as outcomes, and with demographic, clinical, and socio-behavioral (including coffee consumption) data as explanatory variables. Among 4746 HBV-infected patients, drinking ≥3 cups of coffee per day was associated with a higher risk of dyslipidemia (adjusted odds ratio [95% confidence interval] 1.49 [1.10–2.00], p = 0.009) and a lower risk of hypertension (0.64 [0.50–0.82], p = 0.001). It was not associated with diabetes. Elevated coffee consumption was associated with a higher risk of dyslipidemia and a lower risk of hypertension in HBV-infected patients, two effects expected to be associated with favorable clinical outcomes. Further studies should test whether such metabolic benefits translate into reduced mortality risk in this population.
登录
查看更多内容
慢性乙型肝炎患者胰岛β细胞功能显着下降与高血糖密切相关。
影响因子：
2.8
作者：
Liu D;Zhou L;Zhang X;Zeng Y;Bai L;Wu D;Tang H
通讯作者：
Tang H
影响因子：
1.3
作者：
Echeverri D;Montes FR;Cabrera M;Galán A;Prieto A
通讯作者：
Prieto A
影响因子：
7.1
作者：
Alperet, Derrick Johnston;Rebello, Salome Antonette;van Dam, Rob M.
通讯作者：
van Dam, Rob M.
DOI：
10.1080/03601234.2020.1724660
发表时间：
2020-02-17
影响因子：
2
作者：
Bobkova, Alica;Hudacek, Marek;Demianova, Alzbeta
通讯作者：
Demianova, Alzbeta
影响因子：
2.5
作者：
Barre, Tangui;Nishimwe, Marie Liberee;Carrieri, Patrizia
通讯作者：
Carrieri, Patrizia