Behavioural consequences of nucleus accumbens dopaminergic stimulation and glutamatergic blocking in pigeons
Behavioural consequences of nucleus accumbens dopaminergic stimulation and glutamatergic blocking in pigeons
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鸽子伏隔核多巴胺能刺激和谷氨酸能阻断的行为后果
DOI：
10.1016/s0166-4328(02)00109-2
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发表时间：
2002
影响因子：
2.7
通讯作者：
J. Delius
中科院分区：
文献类型：
--
作者：
M. Acerbo;P. Gargiulo;Ines Krug;J. Delius
在系统性给予阿扑吗啡（一种有效的多巴胺激动剂）后，鸽子表现出一系列啄行为。当药物被重复施用时，发生与明显的辨别学习相关的敏化。在这里，我们表明，脑内注射阿扑吗啡在周围的核的鸽子也引起啄。我们还表明，注射5-氨基-膦酰hepatnoic酸，一种NMDA-谷氨酸受体阻滞剂，到ACC损害的表现，学习的视觉歧视，将啄食作为一个选择的反应。我们的结论是，因为它是在哺乳动物中的情况下，控制机制的学习感觉运动的行为在鸟类涉及多巴胺和nucleus神经元区域内的突触传递。
Upon systemic administration of apomorphine, a potent dopamine agonist, pigeons show a bout of pecking behaviour. When the drug is repeatedly administered a sensitization takes place that is associated with pronounced discrimination learning. Here we show that intra-cerebral injections of apomorphine in the periphery of the nucleus accumbens of pigeons also elicit pecking. We additionally show that injections of 5-amino-phosphonohepatnoic acid, a NMDA-glutamate receptor blocker, into the Acc impairs the performance of a learned visual discrimination incorporating pecking as a choice response. We conclude that, as it is the case in mammals, the control mechanisms of learned sensory-motor behaviour in birds involves dopaminergic and glutamatergic synaptic transmission within the nucleus accumbens area.
大鼠脑组织中阿朴啡对映体的受体亲和力。
影响因子：
5
作者：
Baldessarini,RJ;Kula,NS;Zong,R;Neumeyer,JL
通讯作者：
Neumeyer,JL