Assessing bioenergetic compromise in autism spectrum disorder with 31P magnetic resonance spectroscopy: preliminary report.
Assessing bioenergetic compromise in autism spectrum disorder with 31P magnetic resonance spectroscopy: preliminary report.
复制标题
DOI：
10.1177/0883073813498466
复制
发表时间：
2014-02
影响因子：
1.9
通讯作者：
Hamilton G
中科院分区：
文献类型：
--
作者：
Golomb BA;Erickson LC;Scott-Van Zeeland AA;Koperski S;Haas RH;Wallace DC;Naviaux RK;Lincoln AJ;Reiner GE;Hamilton G
We sought to examine, via Phosphorus-31 magnetic resonance spectroscopy (31P-MRS) in a case-control design, whether bioenergetic deficits in autism spectrum disorders extend to brain and muscle. Six cases with autism spectrum disorder with suspected mitochondrial dysfunction (age 6–18 years) and six age/sex-matched controls underwent 31P-MRS. The outcomes of focus were muscle resting phosphocreatine and intracellular pH; as well as post-exercise phosphocreatine-recovery-time-constant; and frontal brain phosphocreatine. Intracellular muscle pH was lower in each autism spectrum disorder case than their matched control (6/6, p=0.03; p=0.0048 paired t-test). Muscle phosphocreatine (5/6), brain phosphocreatine (3/4), and muscle phosphocreatine-recovery-time-constant (3/3) trends were in the predicted direction (not all participants completed each). This study introduces 31P-MRS as a noninvasive tool for assessment of mitochondrial function in autism spectrum disorder enabling bioenergetic assessment in brain; and provides preliminary evidence suggesting bioenergetic defects in cases with autism spectrum disorder are present in muscle and may extend to brain.
登录
查看更多内容
影响因子：
9.9
作者：
Bernier, FP;Boneh, A;Thorburn, DR
通讯作者：
Thorburn, DR
影响因子：
3.9
作者：
Erickson, Laura C.;Scott-Van Zeeland, Ashley A.;Hamilton, Gavin;Lincoln, Alan;Golomb, Beatrice A.
通讯作者：
Golomb, Beatrice A.
影响因子：
1.9
作者：
Poling, Jon S.;Frye, Richard E.;Zimmerman, Andrew W.
通讯作者：
Zimmerman, Andrew W.
影响因子：
11.2
作者：
Filipek, PA;Juranek, J;Gargus, JJ
通讯作者：
Gargus, JJ
影响因子：
3.9
作者：
Lord, C;Risi, S;Rutter, M
通讯作者：
Rutter, M