Brief report: approaches to 31P-MRS in awake, non-sedated children with and without autism spectrum disorder.

Brief report: approaches to 31P-MRS in awake, non-sedated children with and without autism spectrum disorder.
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DOI:
10.1007/s10803-011-1359-x
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发表时间:
2012-06
影响因子:
3.9
通讯作者:
Golomb, Beatrice A.
Golomb, Beatrice A.
中科院分区:
心理学3区
文献类型:
--
作者:
Erickson, Laura C.;Scott-Van Zeeland, Ashley A.;Hamilton, Gavin;Lincoln, Alan;Golomb, Beatrice A.

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我们试验了一套方法,旨在促进一个成功的系列多达四个大脑和肌肉31磷磁共振波谱(31 P-MRS)扫描在一个会议中进行12清醒,非镇静受试者(6 - 18岁),6自闭症谱系障碍(ASD)和6个控制。我们的目标是先进的准备,父母的投入,身体舒适,短扫描协议,分配额外的时间,和受试者的情感支持。100%的受试者完成了至少一次脑部扫描和一次腿部肌肉扫描:46次尝试扫描中有42次完成(91%),失败主要是运动肌肉扫描(6/6例对照完成,3/6例病例完成)。一次完成的扫描缺少与受试者/扫描程序无关的可用数据(脑损伤影响了额叶扫描)。作为一个组,这些方法为在ASD儿科受试者中进行和加强未来的MR研究提供了基础。
We piloted a suite of approaches aimed to facilitate a successful series of up to four brain and muscle 31Phosphorus-Magnetic Resonance Spectroscopy (31P-MRS) scans performed in one session in 12 awake, non-sedated subjects (ages 6 – 18), 6 with autism spectrum disorders (ASD) and 6 controls. We targeted advanced preparation, parental input, physical comfort, short scan protocols, allocation of extra time, and subject emotional support. 100% of subjects completed at least one brain scan and one leg muscle scan: 42 of 46 attempted scans were completed (91%), with failures dominated by exercise muscle scans (completed in 6/6 controls but 3/6 cases). One completed scan lacked usable data unrelated to subject/scan procedure (orthodonture affected a frontal brain scan). As a group, these methods provide a foundation for conduct and enhancement of future MR studies in pediatric subjects with ASD.
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