Approaches for Regenerative Healing of Cutaneous Wound with an Emphasis on Strategies Activating the Wnt/β-Catenin Pathway.
Approaches for Regenerative Healing of Cutaneous Wound with an Emphasis on Strategies Activating the Wnt/β-Catenin Pathway.
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皮肤伤口再生愈合的途径，重点是激活Wnt/β-Catenin通路的策略。
DOI：
10.1089/wound.2020.1284
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发表时间：
2022-02
影响因子：
4.9
通讯作者：
Choi, Kang-Yell
中科院分区：
文献类型：
--
作者：
Choi, Sehee;Yoon, Minguen;Choi, Kang-Yell
在成年哺乳动物中，皮肤伤口的自发修复发生缓慢，并留下带有皮肤附件缺陷的疤痕。为了加速皮肤伤口的愈合速度和避免疤痕的形成，目前的研究集中在再生疗法上。再生伤口愈合的新疗法通常集中在生长因子和干细胞的使用上。然而，由于高成本和技术要求，这些治疗方法的常规临床应用有限。了解皮肤创面愈合信号通路的分子机制和皮肤成分的新生合成对于发现再生创面愈合药物的新靶点非常重要。众所周知，Wnt/β-catenin通路通过与其他信号通路的串扰，促进了组织再生的整体愈合过程。通过调节通路控制因子激活Wnt/β-catenin通路的策略可以为再生伤口愈合提供有效的治疗方法。
In adult mammals, spontaneous repair of a cutaneous wound occurs slowly and leaves a scar with skin adnexa deficiencies. To accelerate cutaneous wound-healing rates and avoid scar formation, current studies have focused on regenerative therapies. Emerging therapeutics for regenerative wound healing often focus on the use of growth factors and stem cells. However, these therapeutic approaches have limited routine clinical use due to high costs and technical requirements. Understanding the molecular mechanisms involved in the signaling pathways for cutaneous wound healing and neogenic synthesis of the skin components is important for identification of novel targets for the development of regenerative wound-healing agents. The Wnt/β-catenin pathway is a well-known key player for enhancement of the overall healing process involving tissue regeneration via crosstalk with other signaling pathways. Strategies that activate the Wnt/β-catenin pathway via modulation of the pathway-controlling regulatory factors could provide effective therapeutic approaches for regenerative wound healing.
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