Cutaneous wound healing: recruiting developmental pathways for regeneration.
Cutaneous wound healing: recruiting developmental pathways for regeneration.
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DOI：
10.1007/s00018-012-1152-9
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发表时间：
2013-06
影响因子：
8
通讯作者：
Alman, Benjamin A.
中科院分区：
文献类型：
--
作者：
Bielefeld, Kirsten A.;Amini-Nik, Saeid;Alman, Benjamin A.
关键词：
皮肤损伤后，受损组织通过构成皮肤愈合反应的协调生物行动得到修复。然而，在哺乳动物中，修复后的皮肤与完整的未损伤皮肤并不相同，这种差异可能是由于与胚胎皮肤发育相比，调节出生后皮肤创伤修复的机制不同造成的。提高我们对参与这些过程的分子通路的理解对于产生伤口愈合并发症的新疗法是至关重要的。在这里，我们重点介绍几个关键的发育信号通路(Wnt/β-catenin，转化生长因子-β，Hedgehog，Notch)在哺乳动物皮肤创伤修复中的作用，并将其与它们在皮肤发育中的作用进行比较。我们讨论了不同分类群对皮肤损伤的不同反应，从完全再生到疤痕组织形成。最后，我们概述了对皮肤修复过程中发育通路的作用的研究如何有助于目前的创伤治疗，并为开发更有效的治疗方法提供了潜力。
Following a skin injury, the damaged tissue is repaired through the coordinated biological actions that constitute the cutaneous healing response. In mammals, repaired skin is not identical to intact uninjured skin, however, and this disparity may be caused by differences in the mechanisms that regulate postnatal cutaneous wound repair compared to embryonic skin development. Improving our understanding of the molecular pathways that are involved in these processes is essential to generate new therapies for wound healing complications. Here we focus on the roles of several key developmental signaling pathways (Wnt/β-catenin, TGF-β, Hedgehog, Notch) in mammalian cutaneous wound repair, and compare this to their function in skin development. We discuss the varying responses to cutaneous injury across the taxa, ranging from complete regeneration to scar tissue formation. Finally, we outline how research into the role of developmental pathways during skin repair has contributed to current wound therapies, and holds potential for the development of more effective treatments.
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影响因子：
23.9
作者：
Brownell, Isaac;Guevara, Elizabeth;Bai, C. Brian;Loomis, Cynthia A.;Joyner, Alexandra L.
通讯作者：
Joyner, Alexandra L.
DOI：
10.3109/08977194.2011.595714
发表时间：
2011-10
期刊：
Growth factors (Chur, Switzerland)
影响因子：
--
作者：
Biernacka A;Dobaczewski M;Frangogiannis NG
通讯作者：
Frangogiannis NG
影响因子：
--
作者：
Alfaro MP;Saraswati S;Young PP
通讯作者：
Young PP
影响因子：
37.8
作者：
Asai, Jun;Takenaka, Hideya;Losordo, Douglas W.
通讯作者：
Losordo, Douglas W.
影响因子：
5.2
作者：
Amini-Nik, Saeid;Glancy, Dylan;Alman, Benjamin A.
通讯作者：
Alman, Benjamin A.