Motor assessment of developing common marmosets
Motor assessment of developing common marmosets
复制标题
发育中的普通狨猴的运动评估
作者：
Yiwen Wang;Qin Fang;Neng Gong
运动发育已经在人类婴儿和儿童中进行了广泛的研究，具有用于评价运动功能的几个已建立的量表。然而，由于缺乏良好的动物模型，对人类运动发育的神经机制的研究受到阻碍。普通绒猴（Callithrix jacchus）是一种新大陆的小型猴，作为了解人类生理和疾病的潜在非人灵长类动物模型，最近引起了人们的广泛关注。然而，很少有人知道它的毛运动的发展。在本研究中，我们发现，绒猴有一个关键时期的运动发育在出生后2至5周，并获得了他们的大部分运动技能的8周龄。我们还开发了方法来评估他们的运动功能，这将是有用的评价在人类疾病的绒猴模型的运动性能。此外，我们发现，绒猴表现出类似于人类的运动发育的“头到尾”序列，进一步支持了这样的观点，即它们为研究人类运动发育的神经机制提供了良好的动物模型。
Motor development has been extensively studied in human infants and children, with several established scales for the evaluation of motor functions. However, the study of the neuronal mechanisms underlying human motor development is hampered by the lack of good animal models. The common marmoset (Callithrix jacchus), a small New World monkey, has recently attracted much attention as a potential nonhuman primate model for understanding human physiology and diseases. However, little is known about its gross motor development. In the present study, we found that marmosets have a critical period for motor development in postnatal weeks 2 to 5, and acquire most of their motor skills by 8 weeks of age. We also developed methods to assess their motor functions, which will be useful for the evaluation of motor performance in marmoset models of human diseases. In addition, we found that marmosets exhibit a “head-to-tail” sequence of motor development similar to that found in humans, further supporting the notion that they provide a good animal model for studying the neuronal mechanisms underlying human motor development.
影响因子：
0.8
作者：
K. Mansfield
通讯作者：
K. Mansfield
影响因子：
56.9
作者：
SCHONER, G;KELSO, JAS
通讯作者：
KELSO, JAS
影响因子：
56.9
作者：
Kordower, JH;Emborg, ME;Aebischer, P
通讯作者：
Aebischer, P