Coupled environmental and demographic fluctuations shape the evolution of cooperative antimicrobial resistance.
Coupled environmental and demographic fluctuations shape the evolution of cooperative antimicrobial resistance.
复制标题
环境和人口的波动共同影响着协同耐药性的演变。
DOI：
10.1098/rsif.2023.0393
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发表时间：
2023-11
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
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迫切需要更好地了解微生物种群如何对抗微生物药物做出反应，并找到可能根除抗菌药物耐药细胞的机制。耐药微生物对抗菌剂的灭活通常可以被视为一种合作行为，导致耐药细胞和敏感细胞在大种群和静态环境中共存。然而，这一情况因易变环境中出现的波动而大大改变，而微生物群落通常在易变环境中进化。在这里，我们研究了由抗微生物耐药菌株和对时间波动环境中的抗微生物药物敏感的微生物组成的种群的生态进化动力学，该种群由丰度和稀缺状态之间随机切换的承载能力建模。我们假设，当耐药细胞的数量超过一定的阈值时，抗菌素耐药性（AMR）是一种共享的公共产品。因此，生态进化动力学的特点是人口噪音（出生和死亡事件）加上环境波动，可能导致人口瓶颈。通过结合分析和计算手段，我们确定了两种菌株长期共存和固定的环境条件，以及波动驱动的AMR根除机制，其中耐药微生物经历了导致灭绝的瓶颈。我们还讨论了我们的研究结果在实验室控制实验中的可能应用。
There is a pressing need to better understand how microbial populations respond to antimicrobial drugs, and to find mechanisms to possibly eradicate antimicrobial-resistant cells. The inactivation of antimicrobials by resistant microbes can often be viewed as a cooperative behaviour leading to the coexistence of resistant and sensitive cells in large populations and static environments. This picture is, however, greatly altered by the fluctuations arising in volatile environments, in which microbial communities commonly evolve. Here, we study the eco-evolutionary dynamics of a population consisting of an antimicrobial-resistant strain and microbes sensitive to antimicrobial drugs in a time-fluctuating environment, modelled by a carrying capacity randomly switching between states of abundance and scarcity. We assume that antimicrobial resistance (AMR) is a shared public good when the number of resistant cells exceeds a certain threshold. Eco-evolutionary dynamics is thus characterised by demographic noise (birth and death events) coupled to environmental fluctuations which can cause population bottlenecks. By combining analytical and computational means, we determine the environmental conditions for the long-lived coexistence and fixation of both strains, and characterise a fluctuation-driven AMR eradication mechanism, where resistant microbes experience bottlenecks leading to extinction. We also discuss the possible applications of our findings to laboratory-controlled experiments.
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影响因子：
5.2
作者：
Dai T;Fuchs BB;Coleman JJ;Prates RA;Astrakas C;St Denis TG;Ribeiro MS;Mylonakis E;Hamblin MR;Tegos GP
通讯作者：
Tegos GP
影响因子：
9.2
作者：
Brockhurst, Michael A.;Buckling, Angus;Gardner, Andy
通讯作者：
Gardner, Andy
影响因子：
7.7
作者：
Coates J;Park BR;Le D;Şimşek E;Chaudhry W;Kim M
通讯作者：
Kim M
影响因子：
28.3
作者：
通讯作者：
--
DOI：
10.1088/1742-5468/2010/09/p09009
发表时间：
2010-09-01
影响因子：
2.4
作者：
Assaf, Michael;Mobilia, Mauro
通讯作者：
Mobilia, Mauro