Calcium affects on vascular endpoints.
Calcium affects on vascular endpoints.
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DOI：
10.1186/1743-7075-9-24
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发表时间：
2012-03-27
影响因子：
4.5
通讯作者：
Bhattacharya RK
中科院分区：
文献类型：
--
作者：
Patel VB;Vacek JL;Graves L;Bhattacharya RK
钙是体内最丰富的矿物质之一，其代谢是人类基本的生物过程之一。尽管历史上钙主要与骨骼结构的发育和维护有关，但现在钙被认为是最佳健康所必需的许多生理途径的关键组成部分，包括心血管、神经、内分泌、肾脏和胃肠系统。 2011 年 8 月发表的一项最新荟萃分析显示，与钙补充剂相关的心血管事件可能会增加。这种相关性的可能作用机制尚未得到很好的阐明。由于钙补充剂的广泛使用，这个话题引起了人们的强烈兴趣，特别是在最容易发生心脏事件的中老年人中。先前的研究没有控制潜在的混杂因素，例如他汀类药物、阿司匹林或其他药物的使用。这些有争议的结果需要额外精心设计的研究来调查钙补充剂与心血管结局之间的关系。本综述的目的是重点介绍有关补钙和心血管健康的最新文献；并确定未来研究的领域。
Calcium is one of the most abundant minerals in the body and its metabolism is one of the basic biologic processes in humans. Although historically linked primarily to bone structural development and maintenance, calcium is now recognized as a key component of many physiologic pathways necessary for optimum health including cardiovascular, neurological, endocrine, renal, and gastrointestinal systems. A recent meta-analysis published in August 2011 showed a potential increase in cardiovascular events related to calcium supplementation. The possible mechanism of action of this correlation has not been well elucidated. This topic has generated intense interest due to the widespread use of calcium supplements, particularly among the middle aged and elderly who are at the most risk from cardiac events. Prior studies did not control for potential confounding factors such as the use of statins, aspirin or other medications. These controversial results warrant additional well-designed studies to investigate the relationship between calcium supplementation and cardiovascular outcomes. The purpose of this review is to highlight the current literature in regards to calcium supplementation and cardiovascular health; and to identify areas of future research.
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影响因子：
158.5
作者：
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通讯作者：
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