The role of phospholipid molecular species in determining the physical properties of yeast membranes.

The role of phospholipid molecular species in determining the physical properties of yeast membranes.
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DOI:
10.1002/1873-3468.12944
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发表时间:
2018-04
期刊:
影响因子:
3.5
通讯作者:
de Kroon AIPM
de Kroon AIPM
中科院分区:
生物学3区
文献类型:
--
作者:
Renne MF;de Kroon AIPM

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In most eukaryotes, including Saccharomyces cerevisiae, glycerophospholipids are the main membrane lipid constituents. Besides serving as general membrane ‘building blocks’, glycerophospholipids play an important role in determining the physical properties of the membrane, which are crucial for proper membrane function. To ensure optimal physical properties, membrane glycerophospholipid composition and synthesis are tightly regulated. This review will summarize our current knowledge of factors and processes determining the membrane glycerophospholipid composition of the reference eukaryote S. cerevisiae at the level of molecular species. Extrapolating from relevant model membrane data, we also discuss how modulation of the molecular species composition can regulate membrane physical properties.
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