Characterization of the sickness response in young and aging rats following E. coli infection.
Characterization of the sickness response in young and aging rats following E. coli infection.
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DOI：
10.1016/j.bbi.2009.01.016
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发表时间：
2009-05
影响因子：
15.1
通讯作者：
Maier, Steven F.
中科院分区：
文献类型：
--
作者：
Barrientos, Ruth M.;Watkins, Linda R.;Rudy, Jerry W.;Maier, Steven F.
为了更全面地描述年轻（3个月）和老年（24个月）大鼠的疾病反应，我们在用E.杆菌在老年大鼠感染后12小时内，CBT的增加被延迟和钝化。事实上，在老年受试者中，最初的反应是体温过低，但随后是持续3天的CBT显著和长期升高。相比之下，年轻的大鼠产生了持续一天多的快速而强劲的CBT升高。活动水平仅在E.年轻和老年大鼠中的大肠杆菌给药。两个年龄组在E.大肠杆菌的管理，虽然有一个趋势，老年大鼠继续失去更多的重量在未来六天比年轻的大鼠。这是第一项在年轻和老年大鼠中长时间检查CBTs的研究，从而揭示了老年大鼠确实有一种夸大的，尽管是延迟的发烧，这与在老年啮齿动物中观察到的其他夸大的疾病行为反应一致。
To more fully characterize the sickness response in young (3 mo) and older (24 mo) rats, we measured core body temperature (CBT), activity level, and body weight changes for seven days following a peripheral immune challenge with E. coli. CBT increases were delayed and blunted during the 12 h following infection in older rats. Indeed, in aging subjects the initial response was hypothermia, but this was followed by a significant and prolonged elevation in CBT lasting 3 days. Young rats, in contrast, generated a rapid and robust CBT elevation lasting just over a day. Activity level was significantly reduced only on the day of E. coli administration in both young and older rats. Body weight loss was equivalent in both age groups one day after E. coli administration, although there was a trend for older rats to continue losing more weight across the next six days than in young rats. This is the first study to examine CBTs in young and older rats for a protracted amount of time, thereby revealing that aging rats do have an exaggerated, albeit delayed, fever which is in keeping with other exaggerated sickness behavioral responses observed in aging rodents.
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DOI：
10.1111/j.1749-6632.1998.tb08321.x
发表时间：
1998-01-01
期刊：
MOLECULAR MECHANISMS OF FEVER
影响因子：
--
作者：
Dantzer, R;Bluthé, RM;Kelley, KW
通讯作者：
Kelley, KW
DOI：
10.1152/ajpregu.00104.2007
发表时间：
2008-07-01
影响因子：
2.8
作者：
Buchanan, Jessica B.;Peloso, Elizabeth;Satinoff, Evelyn
通讯作者：
Satinoff, Evelyn
影响因子：
5.5
作者：
Dilger, Ryan N.;Johnson, Rodney W.
通讯作者：
Johnson, Rodney W.
影响因子：
4.2
作者：
Frank, MG;Barrientos, RA;Maier, SF
通讯作者：
Maier, SF
影响因子：
4.8
作者：
Godbout, JP;Chen, J;Johnson, RW
通讯作者：
Johnson, RW