Prevention of cholesterol gallstones by inhibiting hepatic biosynthesis and intestinal absorption of cholesterol.
Prevention of cholesterol gallstones by inhibiting hepatic biosynthesis and intestinal absorption of cholesterol.
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DOI：
10.1111/eci.12058
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发表时间：
2013-04
影响因子：
5.5
通讯作者：
Wang DQ
中科院分区：
文献类型：
--
作者：
Wang HH;Portincasa P;de Bari O;Liu KJ;Garruti G;Neuschwander-Tetri BA;Wang DQ
胆固醇胆石症是一种多因素疾病，受遗传和环境因素的复杂相互作用的影响，代表胆汁胆固醇稳态的失败，其中胆汁中胆固醇溶解度的物理化学平衡被扰乱。主要的病理生理事件是胆汁胆固醇的持续肝脏分泌过多，其具有肝脏和小肠成分。大多数环境因素可能与西方式的饮食习惯有关，包括过量的胆固醇摄入。腹腔镜胆囊切除术是美国最常见的外科手术之一，目前是胆结石的主要治疗方法。然而，它是侵入性的，可能导致手术并发症，并不是所有有症状的胆结石患者都适合手术。亲水性胆汁酸，熊去氧胆酸（UDCA）已被用作小的放射性胆固醇结石的症状性患者亚组的一线药物治疗。长期服用UDCA可促进胆固醇结石的溶解。然而，由于未能充分滴定剂量，在临床实践中并不总能实现UDCA的最佳使用。因此，开发新的，有效的和非侵入性的治疗方法对于降低与胆结石相关的医疗费用至关重要。在这篇综述中，我们总结了最近的进展调查依折麦布和他汀类药物对肠道吸收和肝脏生物合成的胆固醇，分别治疗胆结石，以及阐明其分子机制，联合治疗可以防止这种非常常见的肝脏疾病在世界范围内。
Cholesterol cholelithiasis is a multifactorial disease influenced by a complex interaction of genetic and environmental factors, and represents a failure of biliary cholesterol homeostasis in which the physical-chemical balance of cholesterol solubility in bile is disturbed. The primary pathophysiologic event is persistent hepatic hypersecretion of biliary cholesterol, which has both hepatic and small intestinal components. The majority of the environmental factors are probably related to Western-type dietary habits, including excess cholesterol consumption. Laparoscopic cholecystectomy, one of the most commonly performed surgical procedures in the US, is nowadays a major treatment for gallstones. However, it is invasive and can cause surgical complications, and not all patients with symptomatic gallstones are candidates for surgery. The hydrophilic bile acid, ursodeoxycholic acid (UDCA) has been employed as first-line pharmacological therapy in a subgroup of symptomatic patients with small, radiolucent cholesterol gallstones. Long-term administration of UDCA can promote the dissolution of cholesterol gallstones. However, the optimal use of UDCA is not always achieved in clinical practice because of failure to titrate the dose adequately. Therefore, the development of novel, effective, and noninvasive therapies is crucial for reducing the costs of health care associated with gallstones. In this review, we summarize recent progress in investigating the inhibitory effects of ezetimibe and statins on intestinal absorption and hepatic biosynthesis of cholesterol, respectively, for the treatment of gallstones, as well as in elucidating their molecular mechanisms by which combination therapy could prevent this very common liver disease worldwide.
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影响因子：
2.9
作者：
Davis, KG;Wertin, TM;Schriver, JP
通讯作者：
Schriver, JP
影响因子：
13.5
作者：
DUANE, WC;HUNNINGHAKE, DB;GEBHARD, RL
通讯作者：
GEBHARD, RL
DOI：
10.1007/bf02020929
发表时间：
1971-01-01
期刊：
ZEITSCHRIFT FUR ERNAHRUNGSWISSENSCHAFT
影响因子：
--
作者：
DAM, H;PRANGE, I;FENGER, HJ
通讯作者：
FENGER, HJ
DOI：
10.1016/0005-2760(94)90096-5
发表时间：
1994-11-17
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM
影响因子：
--
作者：
BRAVO, E;BOTHAM, KM;CANTAFORA, A
通讯作者：
CANTAFORA, A
影响因子：
37.8
作者：
Ballantyne, CM;Houri, J;Veltri, EP
通讯作者：
Veltri, EP