Delayed convergence between brain network structure and function in rolandic epilepsy.
Delayed convergence between brain network structure and function in rolandic epilepsy.
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DOI：
10.3389/fnhum.2014.00704
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发表时间：
2014
影响因子：
2.9
通讯作者：
Backes WH
中科院分区：
文献类型：
--
作者：
Besseling RM;Jansen JF;Overvliet GM;van der Kruijs SJ;Ebus SC;de Louw AJ;Hofman PA;Aldenkamp AP;Backes WH
罗兰性癫痫（RE）在大脑发育的关键阶段表现出来，并与语言障碍有关。结构和功能连通性（SC和FC）的一致性异常之前已经描述过。由于SC和FC相互影响，本研究探讨了RE中SC-FC协同作用的异常情况。方法：22名RE患儿（年龄，平均±SD: 11.3±2.0 y）和22名健康对照（年龄10.5±1.6 y）在3T时进行结构、扩散加权和静息状态功能磁共振成像（MRI）。概率解剖标志图谱用于皮质灰质（下）包裹。约束球面反褶积示踪和时间序列相关分别用于评估SC和FC。SC-FC相关性作为非零结构连接在稀疏值范围内（0.01-0.75）的年龄函数进行评估。对控制的平均SC网络进行了模块化分析，以将潜在的全局影响定位到子网。SC和FC也分别用图表分析进行评估。结果：与健康对照相比，RE患儿的SC-FC相关性显著降低，尤其是最年轻的参与者。这种效应在左、右中央颞网络以及内侧顶叶网络中最为明显。图分析显示SC或FC网络组织无明显异常。结论：由于SC和FC在正常成熟过程中收敛，我们发现SC-FC相关性降低说明大脑结构和功能之间的协同作用受损。更具体地说，由于这种影响在最年轻的参与者中最为明显，RE可能代表了一种延迟脑网络成熟的发育障碍。观察到的效果似乎特别归因于内侧顶叶连接，它形成了癫痫样活动的双侧中央-颞叶模块之间的中间部分，并与语言功能相关。
Introduction: Rolandic epilepsy (RE) manifests during a critical phase of brain development, and has been associated with language impairments. Concordant abnormalities in structural and functional connectivity (SC and FC) have been described before. As SC and FC are under mutual influence, the current study investigates abnormalities in the SC-FC synergy in RE. Methods: Twenty-two children with RE (age, mean ± SD: 11.3 ± 2.0 y) and 22 healthy controls (age 10.5 ± 1.6 y) underwent structural, diffusion weighted, and resting-state functional magnetic resonance imaging (MRI) at 3T. The probabilistic anatomical landmarks atlas was used to parcellate the (sub)cortical gray matter. Constrained spherical deconvolution tractography and correlation of time series were used to assess SC and FC, respectively. The SC-FC correlation was assessed as a function of age for the non-zero structural connections over a range of sparsity values (0.01–0.75). A modularity analysis was performed on the mean SC network of the controls to localize potential global effects to subnetworks. SC and FC were also assessed separately using graph analysis. Results: The SC-FC correlation was significantly reduced in children with RE compared to healthy controls, especially for the youngest participants. This effect was most pronounced in a left and a right centro-temporal network, as well as in a medial parietal network. Graph analysis revealed no prominent abnormalities in SC or FC network organization. Conclusion: Since SC and FC converge during normal maturation, our finding of reduced SC-FC correlation illustrates impaired synergy between brain structure and function. More specifically, since this effect was most pronounced in the youngest participants, RE may represent a developmental disorder of delayed brain network maturation. The observed effects seem especially attributable to medial parietal connections, which forms an intermediate between bilateral centro-temporal modules of epileptiform activity, and bear relevance for language function.
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影响因子：
3.7
作者：
Besseling, Rene M. H.;Jansen, Jacobus F. A.;Backes, Walter H.
通讯作者：
Backes, Walter H.
影响因子：
4.2
作者：
Besseling, Rene M. H.;Jansen, Jacobus F. A.;Backes, Walter H.
通讯作者：
Backes, Walter H.
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
DOI：
10.1177/155005949802900305
发表时间：
1998-07-01
期刊：
CLINICAL ELECTROENCEPHALOGRAPHY
影响因子：
--
作者：
Graf, M;Lischka, A
通讯作者：
Lischka, A
影响因子：
9.9
作者：
Massa, R;de Saint-Martin, A;Marescaux, C
通讯作者：
Marescaux, C