Successful Treatment of Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Patients With Immunodeficiency With Extended Nirmatrelvir/Ritonavir: Case Series.

Successful Treatment of Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Patients With Immunodeficiency With Extended Nirmatrelvir/Ritonavir: Case Series.
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DOI:
10.1093/ofid/ofad189
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发表时间:
2023-04
影响因子:
4.2
通讯作者:
--
中科院分区:
医学3区
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--
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伴有b细胞缺陷的免疫功能低下患者存在长期有症状的严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)感染的风险。我们描述了4例使用b细胞消耗疗法治疗b细胞恶性肿瘤的患者,他们出现了持续的SARS-CoV-2感染,并在延长尼马特利韦/利托那韦疗程后症状得到缓解。
Immunocompromised patients with B-cell deficiencies are at risk for prolonged symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We describe 4 patients treated for B-cell malignancies with B-cell-depleting therapies who developed persistent SARS-CoV-2 infection and had resolution of symptoms following an extended course of nirmatrelvir/ritonavir.
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