Immunocompromised Patients with Protracted COVID-19: a Review of "Long Persisters".
Immunocompromised Patients with Protracted COVID-19: a Review of "Long Persisters".
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DOI：
10.1007/s40472-022-00385-y
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发表时间：
2022
影响因子：
2.1
通讯作者：
Haidar, Ghady
中科院分区：
文献类型：
--
作者：
Dioverti, Veronica;Salto-Alejandre, Sonsoles;Haidar, Ghady
某些免疫功能低下的人有患迁延性新冠肺炎的风险，在这种情况下，SARS-CoV-2会导致慢性病毒感染。然而，这一现象的发病机制、诊断和处理仍不明确。在这里，我们回顾了免疫受损个体中SARS-CoV-2长期感染的关键方面，并描述了这种情况的临床表现、风险因素、诊断和治疗方式，以及宿主内病毒的演变。在现有数据的基础上，我们还提出了一个处理这种综合征的标准框架。迁延性新冠肺炎是一种影响B细胞耗竭患者的无特征综合征；我们建议的诊断方法和定义将为未来亟需的研究提供信息。
Certain immunocompromised individuals are at risk for protracted COVID-19, in which SARS-CoV-2 leads to a chronic viral infection. However, the pathogenesis, diagnosis, and management of this phenomenon remain ill-defined. Herein, we review key aspects of protracted SARS-CoV-2 infection in immunocompromised individuals, or the so-called long persisters, and describe the clinical presentation, risk factors, diagnosis, and treatment modalities of this condition, as well as intra-host viral evolution. Based on the available data, we also propose a framework of criteria with which to approach this syndrome. Protracted COVID-19 is an uncharacterized syndrome affecting patients with B-cell depletion; our proposed diagnostic approach and definitions will inform much needed future research.
影响因子：
4.7
作者：
Capoluongo E;Nardelli C;Esposito MV;Buonomo AR;Gelzo M;Pinchera B;Zappulo E;Viceconte G;Portella G;Setaro M;Gentile I;Castaldo G
通讯作者：
Castaldo G
影响因子：
1.1
作者：
Daher A;Müller T;Spiesshoefer J;Dreher M;Panse J
通讯作者：
Panse J
影响因子：
3.7
作者：
Phillips SP;Wei X;Kwong JC;Gubbay J;Schwartz KL;Majury A;Groome PA
通讯作者：
Groome PA