Calibration-free technique for the measurement of oxygen saturation changes in muscles of marine mammals and its proof of concept
Calibration-free technique for the measurement of oxygen saturation changes in muscles of marine mammals and its proof of concept
复制标题
用于测量海洋哺乳动物肌肉氧饱和度变化的免校准技术及其概念验证
DOI：
10.1117/12.2290546
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Demos, Stavros G.
中科院分区：
文献类型：
--
作者：
Ortega-Martinez, Antonio;Hindle, Allyson;Franco, Walfre;Booker, Marloes;Goenka, Chhavi;Grange, Robert M.;Alfano, Robert R.;Demos, Stavros G.
海洋哺乳动物拥有令人印象深刻的屏气能力，这是通过潜水过程中的生理调整而实现的。在自然环境中研究海洋哺乳动物可以揭示有关这些生理调整的重要信息，特别是当我们可以监测因人为引起的海洋扰动、捕食者的存在和猎物分布变化等压力情况而改变的潜水行为时。淹没期间生理状态的一个重要指标是这些哺乳动物肌肉和血液中氧饱和度的变化。在这项工作中，我们的目标是研究自由潜水象海豹在海上受到声纳或捕食者声音等干扰时肌肉中的氧气储存和消耗。光学氧传感器是一项具有多种医疗应用的成熟技术，提供了一种以微创方式测量生物组织中氧合变化的方法。虽然这些传感器经过良好校准并且易于人类使用，但它们仍然不足以用于海洋哺乳动物，这主要是由于测试候选数量非常少，因此可用于验证和校准的数据很少。我们提出了一种探针几何结构和相关的数学模型，用于基于近红外漫射传输测量海豹的肌肉氧合，无需校准。基于这个概念的原型已经设计出来并在人类和老鼠身上进行了测试。我们使用测试结果来讨论该方法的优点和局限性。我们还详细介绍了密封件独特的生物学特性对尺寸、传感器位置、电子设备、光源特性和探测器特性的限制。
Marine mammals possess impressive breath-holding capabilities made possible by physiological adjustments during dives. Studying marine mammals in their natural environment unravels vital information about these physiological adjustments particularly when we can monitor altered dive behavior in response to stressful situations such as human-induced oceanic disturbances, presence of predators and altered prey distributions. An important indicator of physiological status during submergence is the change in oxygen saturation in the muscles and blood of these mammals. In this work, we aim to investigate oxygen storage and consumption in the muscles of free-diving elephant seals when exposed to disturbances such as sonar or predator sounds while they are at sea. Optical oxygen sensors are a mature technology with multiple medical applications that provide a way to measure oxygenation changes in biological tissues in a minimally invasive manner. While these sensors are well calibrated and readily available for humans, they are still inadequate for marine mammals primarily due to a very small number of test candidates and therefore little data is available for validation and calibration. We propose a probe geometry and associated mathematical model for measuring muscle oxygenation in seals based on near infrared diffuse transport with no need for calibration. A prototype based on this concept has been designed and tested on humans and rats. We use the test results to discuss the advantages and limitations of the approach. We also detail the constraints on size, sensor location, electronics, light source properties and detector characteristics posed by the unique biology of seals.
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影响因子：
2.8
作者：
Cassondra L. Williams;J. Meir;P. Ponganis
通讯作者：
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影响因子：
2.8
作者：
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通讯作者：
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影响因子：
2.9
作者：
Sevick,EM;Chance,B;Leigh,J;Nioka,S;Maris,M
通讯作者：
Maris,M
DOI：
10.1152/ajpregu.00247.2009
发表时间：
2009-10-01
影响因子：
2.8
作者：
Meir, Jessica U.;Champagne, Cory D.;Ponganis, Paul J.
通讯作者：
Ponganis, Paul J.