Enteral IGF-I enhances fetal growth and gastrointestinal development in oesophageal ligated fetal sheep.
Enteral IGF-I enhances fetal growth and gastrointestinal development in oesophageal ligated fetal sheep.
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肠内 IGF-I 可促进食管结扎胎羊的胎儿生长和胃肠道发育。
DOI：
10.1677/joe.0.1620227
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
J. E. Harding
中科院分区：
文献类型：
--
作者：
Roy M. Kimble;B. Breier;P. D. Gluckman;J. E. Harding
上消化道闭锁的婴儿通常有宫内发育和肠道功能受损。IGF-I在胎儿生长中很重要，并包含在羊水中。因此，我们想测试的假设，胰岛素样生长因子-I注入胎儿肠道将扭转上肠梗阻的影响，肠道结构和生长的胎羊。在妊娠90天时，对胎仔（每组n=6）进行食管结扎，然后在结扎后连续输注IGF-I（1-8微克/天）或盐水至肠道，直至137天。对照组仅进行假结扎。食管结扎倾向于降低胎仔体重和器官重量。IGF-I治疗防止了这种减少，并增加了体长和脾脏重量高于对照组。IGF-I治疗也可预防食管结扎引起的肠壁厚度减少。羊水IGF-I浓度在妊娠期间没有变化，IGF-I治疗组较高。未检测到胎儿血浆IGF-I浓度的变化。我们的结论是，肠内注射IGF-I可以促进胎儿生长和肠道发育在子宫内，IGF-I在羊水中可能发挥生理作用，在胎儿肠道发育。
Infants with upper gut atresia often have impaired intrauterine growth and gut function. IGF-I is important in fetal growth and is contained in amniotic fluid. We therefore wanted to test the hypothesis that IGF-I infused into fetal gut would reverse the effects of an upper gut obstruction on gut structure and growth in fetal sheep. At 90 days gestation fetuses (n=6 per group) underwent oesophageal ligation, followed by continuous infusion of IGF-I (1-8 microgram/day) or saline into the gut beyond the ligation until 137 days. Controls underwent sham ligation only. Oesophageal ligation tended to reduce fetal body and organ weights. IGF-I treatment prevented this reduction and increased body length and spleen weight above those of controls. The decrease in bowel wall thickness induced by oesophageal ligation was also prevented by IGF-I treatment. Amniotic fluid IGF-I concentrations did not change over gestation and were higher in the IGF-I treated group. No change in fetal plasma IGF-I concentrations were detectable. We conclude that enterally administered IGF-I may enhance fetal growth and gut development in utero and that IGF-I in amniotic fluid may play a physiological role in gut development in the fetus.
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DOI：
10.1152/ajpcell.1992.262.1.c207
发表时间：
1992
期刊：
The American journal of physiology
影响因子：
--
作者：
McRoberts,JA;Riley,NE
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Riley,NE
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10.1172/jci115189
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1991-05
期刊：
The Journal of clinical investigation
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作者：
Monica C. Chen;Alexander T. Lee;A. H. Soll
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Monica C. Chen;Alexander T. Lee;A. H. Soll
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10.1210/jcem-59-4-752
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1984
期刊：
The Journal of clinical endocrinology and metabolism
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Merimee,TJ;Grant,M;Tyson,JE
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Tyson,JE
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10.1152/ajpregu.1985.249.1.r133
发表时间：
1985
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The American journal of physiology
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Longo,LD
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发表时间：
1981
期刊：
Journal of developmental physiology
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--
作者：
Bristow,J;Rudolph,AM;Itskovitz,J
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Itskovitz,J