Cathepsin B as a cancer target.
Cathepsin B as a cancer target.
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DOI：
10.1517/14728222.2013.740461
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发表时间：
2013-03
影响因子：
5.8
通讯作者：
Rao JS
中科院分区：
文献类型：
--
作者：
Gondi CS;Rao JS
组织蛋白酶B对癌症治疗具有重要意义，因为它参与了人类的各种病理和致癌过程。大量研究表明，组织蛋白酶B的过度表达与肿瘤的侵袭和转移表型有关。研究表明，组织蛋白酶B的异常调节导致细胞获得致癌特性。组织蛋白酶B通常与参与自噬和免疫反应的溶酶体有关，但其异常表达已被证明会导致癌症。组织蛋白酶B的蛋白水解性归因于肿瘤细胞的浸润性，研究表明，组织蛋白酶B分泌到细胞外基质(ECM)中，从而促进其破坏。研究表明，抑制组织蛋白酶B的蛋白分解活性可以延缓肿瘤细胞的侵袭行为。进一步通过反义或RNAi抑制组织蛋白酶B的表达也能抑制肿瘤的生长。此外，研究表明，联合抑制各种分子，如蛋白酶和包括组织蛋白酶B在内的蛋白酶受体，可以显著抑制肿瘤生长。因此，靶向组织蛋白酶B的活性或表达对于肿瘤治疗具有重要的治疗意义。
Cathepsin B is of significant importance to cancer therapy as it is involved in various pathologies and oncogenic processes in humans. Numerous studies have shown that cathepsin B overexpression is correlated with invasive and metastatic phenotypes in cancers. Studies have shown that abnormal regulation of cathepsin B causes cells to acquire an oncogenic character. Cathepsin B is normally associated with the lysosomes involved in autophagy and immune response, but its aberrant expression has been shown to lead to cancers. The proteolytic nature of cathepsin B has been attributed to the infiltrative nature of tumor cells, and it has been shown that cathepsin B is secreted into the extracellular matrix (ECM), thereby facilitating its destruction. Studies have demonstrated that suppression of the proteolytic activity of cathepsin B retards the infiltrative behavior of tumor cells. Further suppression of the expression of cathepsin B via antisense or RNAi also resulted in suppression of tumor growth. In addition, studies have shown that combined suppression of various molecules, such as proteases and protease receptors, including cathepsin B, can significantly suppress tumor growth. Therefore, targeting the activity or expression of cathepsin B is of significant therapeutic importance for cancer treatment.
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影响因子：
3.7
作者：
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DOI：
10.1073/pnas.1115091109
发表时间：
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作者：
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通讯作者：
Rao JS
影响因子：
5.7
作者：
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通讯作者：
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